Clinical trial Recruiting at 1 site Interventional Ages 21 to 29

How romantic conflict affects drinking and stress responses in young adult couples

Official title: Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults

Run by New York University · NCT06976528 · Data updated 2026-11-12

This project will see if moments of relationship conflict are linked to immediate changes in drinking and body stress signals in 21–29 year-old couples who engage in heavy episodic drinking.

More Heavy Drinking trials

Quick facts

Study typeInterventional
Ages21 Years to 29 Years
SexAll
Enrollment160 (estimated)
SponsorNew York University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedSeptember 26, 2025
Main results expectedJuly 31, 2028
Study endsJuly 31, 2028
Registry record updatedAugust 10, 2026
Trial IDNCT06976528 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are 21–29 year-olds in a committed romantic relationship of at least three months who report at least two heavy episodic drinking episodes in the past 30 days and meet the study's health and weight criteria.

Probably not a fit

People outside the 21–29 age range, those not in a committed relationship, individuals currently in treatment for substance use, or those with serious psychiatric, neurological, or cardiac conditions are excluded and unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Young adult romantic partners who report recent heavy episodic drinking will come to a New York University laboratory and complete two conflict discussion tasks interleaved with two puzzle tasks. During the visit participants will undergo two controlled alcohol administration procedures while continuous physiological data, including high-frequency heart rate variability (HF-HRV), are recorded. The design compares behavioral and physiological responses during conflict and non-conflict periods and relates those responses to subsequent alcohol intake. The goal is to identify risk and resilience factors that connect acute relationship stress to drinking in emerging adults.

Why it matters

Potential benefit: If successful, this work could help clinicians and couples-targeted programs reduce binge drinking by identifying momentary triggers and physiological markers that signal increased drinking risk.

How similar studies have gone: Previous research has linked partner influence, lab-based alcohol administration, and HF-HRV separately to drinking and stress, but combining couple conflict tasks with alcohol challenges and continuous HF-HRV monitoring in emerging adults is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age 21-29 years old
2. Must be in a committed romantic relationship of at least 3 months duration
3. Must report at least 2 HED episodes in the past 30 days (5 or more drinks within 2 hours for males, 4 or more drinks within 2 hours for females)
4. Must self-report that they have - on at least three occasions during the past year - consumed a quantity of alcohol that is equal to or greater than the standard dose administered for their weight in the laboratory

Exclusion Criteria:

1. Meeting DSM-5 criteria for a history of or current neurological, psychotic, or bipolar disorders
2. History of self-reported head trauma requiring medical treatment
3. Body weight exceeding 250 pounds
4. Current enrollment in treatment or seeking treatment for a substance or alcohol use disorder
5. Current suicidal or homicidal intent
6. Serious cardiovascular health conditions (e.g. pacemaker, cardiac arrhythmia, hypertension) that may alter normative cardiac functioning
7. Treatment on medications such as lithium, methadone, alpha or beta blockers or cholinergic/anticholinergic medications likely to confound normative cardiovascular responding or response to alcohol administration. Stimulant or benzodiazepine medication use is permissible provided participants do not take medication on the day of study participation
8. Severe and/or unilateral physical IPV with your current partner at any time
9. Sexual IPV with current partner at any time
10. Fear of current partner
11. Pregnancy or breastfeeding
12. Severe Alcohol Use Disorder (as defined by the DSM-5)
13. Current diagnosis of anorexia or bulimia

Where it's running

  • 386 Park Avenue South
    New York, New York, United States
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.