How probiotics affect survival, treatment response, and gut microbiota during cancer therapy
Official title: The Effect of Survival, Response and Microbiota Change in Different Therapy Under Probiotic Supplement (Clostridium Butyricum) in Patient With Malignant Tumor
Run by Chang Gung Memorial Hospital · NCT06998823 · Data updated 2026-11-12
This test will see if taking a probiotic supplement during cancer treatment helps adults with cancer live longer, respond better to therapy, or have healthier gut bacteria.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (New Taipei City) |
| Status | Recruiting |
| Started | March 20, 2024 |
| Main results expected | October 25, 2025 |
| Study ends | November 8, 2026 |
| Registry record updated | May 31, 2025 |
| Trial ID | NCT06998823 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20 or older with a confirmed cancer diagnosis who are undergoing cancer therapy and can give informed consent are ideal candidates.
✕Probably not a fit
People under age 20, and pregnant or breastfeeding individuals are excluded and would not qualify to receive potential benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study gives an oral probiotic supplement to adults with confirmed cancer who are receiving cancer therapy and follows them over time. Researchers will track clinical outcomes such as survival and treatment response while measuring changes in the gut microbiota. Stool and clinical data will be collected at scheduled visits to compare microbiome composition and clinical outcomes before and after probiotic use. Participants younger than 20 and pregnant or breastfeeding people are excluded from participation.
Why it matters
Potential benefit: If successful, the probiotic could improve treatment response, support gut microbial balance, and potentially improve survival or reduce therapy-related complications.
How similar studies have gone: Prior small clinical and preclinical studies suggest probiotics can modify the gut microbiome and influence treatment responses, but strong evidence for improved survival in cancer patients is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. age≧20 2. participants with cancer therapy and agree to sign informed consent 3. Cancer confirmed by clinical or pathological diagnosis Exclusion Criteria: 1. age\<20 2. Pregnant or breastfeeding women
Where it's running
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New Taipei City TuCheng Hospital
New Taipei City, Taiwan Recruiting
Study contacts
- Principal investigator: Chia-Hsun Hsieh, PhD — Division of Oncology, Chang Gung Memorial Hospital
- Study coordinator: HaoTsai Cheng, PhD
- Email: hautai@cgmh.org.tw
- Phone: 03-3281200
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.