Clinical trial Recruiting at 1 site Interventional Ages 20 and up

How probiotics affect survival, treatment response, and gut microbiota during cancer therapy

Official title: The Effect of Survival, Response and Microbiota Change in Different Therapy Under Probiotic Supplement (Clostridium Butyricum) in Patient With Malignant Tumor

Run by Chang Gung Memorial Hospital · NCT06998823 · Data updated 2026-11-12

This test will see if taking a probiotic supplement during cancer treatment helps adults with cancer live longer, respond better to therapy, or have healthier gut bacteria.

Quick facts

Study typeInterventional
Ages20 Years and up
SexAll
Enrollment120 (estimated)
SponsorChang Gung Memorial Hospital
Academic / other
Drugs / interventionschemotherapy, immunotherapy
Locations1 site (New Taipei City)
StatusRecruiting
StartedMarch 20, 2024
Main results expectedOctober 25, 2025
Study endsNovember 8, 2026
Registry record updatedMay 31, 2025
Trial IDNCT06998823 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 20 or older with a confirmed cancer diagnosis who are undergoing cancer therapy and can give informed consent are ideal candidates.

Probably not a fit

People under age 20, and pregnant or breastfeeding individuals are excluded and would not qualify to receive potential benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study gives an oral probiotic supplement to adults with confirmed cancer who are receiving cancer therapy and follows them over time. Researchers will track clinical outcomes such as survival and treatment response while measuring changes in the gut microbiota. Stool and clinical data will be collected at scheduled visits to compare microbiome composition and clinical outcomes before and after probiotic use. Participants younger than 20 and pregnant or breastfeeding people are excluded from participation.

Why it matters

Potential benefit: If successful, the probiotic could improve treatment response, support gut microbial balance, and potentially improve survival or reduce therapy-related complications.

How similar studies have gone: Prior small clinical and preclinical studies suggest probiotics can modify the gut microbiome and influence treatment responses, but strong evidence for improved survival in cancer patients is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. age≧20
2. participants with cancer therapy and agree to sign informed consent
3. Cancer confirmed by clinical or pathological diagnosis

Exclusion Criteria:

1. age\<20
2. Pregnant or breastfeeding women

Where it's running

  • New Taipei City TuCheng Hospital
    New Taipei City, Taiwan
    Recruiting

Study contacts

  • Principal investigator: Chia-Hsun Hsieh, PhD — Division of Oncology, Chang Gung Memorial Hospital
  • Study coordinator: HaoTsai Cheng, PhD
  • Email: hautai@cgmh.org.tw
  • Phone: 03-3281200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.