How often H. pylori comes back and what affects its return.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study follows adults with confirmed H. pylori infection who completed medical eradication therapy and tracks them over time for recurrence. Participants will undergo periodic testing (urea breath test, stool antigen, or endoscopy/biopsy when indicated) and clinical assessments to document any return of infection. Investigators will collect data on the eradication regimen used, medication adherence, demographics, and comorbidities to identify factors associated with recurrence. The primary outcomes are recurrence rate and differences in recurrence between treatment approaches.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: 18-75 years old.
* H. pylori infection: Confirmed by endoscopy, biopsy, or non-invasive tests (e.g., urea breath test, stool antigen test).
* Symptoms: Presence of dyspepsia, peptic ulcer disease, or other H. pylori-related symptoms.
* Laboratory tests: Normal liver and kidney function, and no significant abnormalities in blood counts.

Exclusion Criteria:

* Patients receiving eradication therapy in the past taking proton pump inhibitors,, H2 blockers ,,bismuth ,, antibiotics or other medications that interfere with the result of the examination in the recent 4 weeks.
* Gastrointestinal disorders: Severe gastrointestinal disorders (e.g., gastric cancer, inflammatory bowel disease ,gastric or duodenal ulcer with current or recent bleeding , or clinical significant gastrointestinal bleeding within 4 weeks of randomization).
* Malignancies: Active or recent malignancies.
* Severe comorbidities: Unstable or severe comorbidities (e.g., heart failure, liver cirrhosis).

Where it's running

• Sohag University Hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Thomas W Thabet, Resident
• Email: thomaswagih0@gmail.com
• Phone: 01286046059

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.