Comparing vonoprazan-based dual and triple treatments with standard PPI triple therapy for H. pylori infection.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-site study enrolls adults with confirmed H. pylori infection who have not previously received H. pylori therapy. Participants are assigned to receive vonoprazan-based dual therapy, vonoprazan-based triple therapy, or a standard proton pump inhibitor (PPI)–based triple therapy for the prescribed treatment course. H. pylori eradication will be checked after treatment using histology or noninvasive tests such as stool antigen, and patients are excluded if they cannot complete therapy or follow-up. The trial is conducted at Sohag University Hospital with routine safety checks for drug allergies and adherence monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: \>18 years old.
* H. pylori infection: Confirmed by histopathology or non-invasive tests (e.g., stool antigen test).

Exclusion Criteria:

* Prior H. pylori treatment: Previous treatment for H. pylori infection.
* Allergies: Known allergies to study medications or components.
* Patients cannot finish treatment course.
* Patient missed follow up.
* Patients refusing or neglecting test of cure for H. pylori.

Where it's running

• Sohag University Hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Andrew K Wadea, Resident
• Email: andrewkameel511@gmail.com
• Phone: 01211498813

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.