How often cannabis-related vomiting sends adults to emergency rooms in Maine-et-Loire
Cannabinoid Hyperemesis Syndrome. Prospective Multicenter Study of Patients Admitted to Adult Emergency Departments in Maine-et-Loire.
University Hospital, Angers · NCT06660901
This study will see how common cannabinoid hyperemesis is in adults 18–65 who come to participating emergency departments with abdominal pain or vomiting.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital, Angers (other gov) |
| Locations | 3 sites (Angers and 2 other locations) |
| Trial ID | NCT06660901 on ClinicalTrials.gov |
What this trial studies
This is a prospective, multicenter observational project enrolling adults aged 18–65 who present to three emergency departments in Maine‑et‑Loire with abdominal pain and/or vomiting during the study period. Patients who can consent complete a questionnaire and are screened for features of cannabinoid hyperemesis, including symptom relief with hot showers, and investigators record cannabis use history and clinical findings. The research team will calculate the prevalence of cannabinoid hyperemesis among eligible ED presentations and describe diagnostic pathways and repeat visit patterns. The study excludes pregnant people and those unable to answer the questionnaire.
Who should consider this trial
Good fit: Adults aged 18–65 who present to the participating emergency departments with abdominal pain and/or vomiting and can give informed consent are the intended participants.
Not a fit: People outside the 18–65 range, pregnant patients, those unable to complete the questionnaire, or patients whose symptoms have a clear alternative diagnosis are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, the study could help emergency clinicians recognize cannabinoid hyperemesis sooner and reduce repeat visits by guiding faster diagnosis and management.
How similar studies have performed: A prior two‑center French emergency department study estimated a 1.6% prevalence among undifferentiated acute abdominal pain cases, so similar observational approaches have produced preliminary prevalence data but broader confirmation is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged 18 to 65 years, * Consulted the Maine et Loire adult emergency department for abdominal pain and/or vomiting for the 1st time during the study period. Exclusion Criteria: * Refusal to participate in the study * Patient unable to answer questionnaire (allophone, under guardianship, under protection, incapable of age, under legal proceedings) * Pregnant women
Where this trial is running
Angers and 2 other locations
- Angers Centre Hospitalier Universitaire (CHU) — Angers, France (RECRUITING)
- Centre Hospitalier de Cholet — Cholet, France (RECRUITING)
- Centre Hospitalier de Saumur — Saumur, France (RECRUITING)
Study contacts
- Principal investigator: Julien DENIS, Doctor — Saumur Hospital Center
- Study coordinator: Julien DENIS, Doctor
- Email: julien.denis@ch-saumur.fr
- Phone: +33 2 41 53 30 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: D000096704, Cannabinoid Hyperemesis Syndrome, marijuana, cannabis, Recurrent vomiting, nausea, abdominal pain, compulsive hot bathing behavior