How often airway closure happens during full ventilator support in the ICU
Annual Prevalence of Airway Closure During the Full Support Phase of Invasive Mechanical Ventilation in Adults in an Intensive Care Unit
We will see how common airway closure is during full ventilator support in adults on invasive mechanical ventilation in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Complejo Médico Churruca Visca Academic / other |
| Locations | 1 site (Buenos Aires, Buenos Aires) |
| Trial ID | NCT07368491 on ClinicalTrials.gov |
What this trial studies
This cross-sectional observational study measures the prevalence of airway closure during the total support phase of invasive mechanical ventilation. Adult ICU patients intubated 48–72 hours who are hemodynamically stable and without respiratory effort will undergo a low-flow maneuver to identify opening pressure. If opening pressure exceeds 5 cmH2O, electrical impedance tomography (EIT) will record regional delays in impedance change across lung quadrants. Secondary analyses will explore clinical, demographic, and ventilatory characteristics associated with airway closure.
Who should consider this trial
Good fit: Adults (≥18 years) in the ICU who were intubated 48–72 hours earlier, are hemodynamically stable, and have no spontaneous respiratory effort are ideal candidates.
Not a fit: Patients with pneumothorax, bronchopleural fistula, suspected elevated intracranial pressure, unstable hemodynamics, or those not on full ventilatory support are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If common predictors of airway closure are identified, clinicians could tailor ventilator settings to reduce collapse and improve oxygenation for affected patients.
How similar studies have performed: Previous observational work using low-flow maneuvers and EIT has reported airway closure and regional delays in ventilated patients, so the methods have precedent though they are not yet routine clinical practice.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years of age * Requiring invasive mechanical ventilation within 48 to 72 hours after orotracheal intubation * Hemodynamically stable (mean arterial pressure greater than 60 mmHg and/or norepinephrine less than 0.5 mcg/kg/min) * Without respiratory muscle effort Exclusion Criteria: * Neumothorax * Bronchopleural fistula * Clinical evidence or suspicion of elevated intracranial pressure (greater than 18 mmHg)
Where this trial is running
Buenos Aires, Buenos Aires
- CMPFA Churruca-Visca — Buenos Aires, Buenos Aires, Argentina (Recruiting)
Study contacts
- Principal investigator: Romina B Mattei — CMPFA Churruca-Visca
- Study coordinator: Romina B Mattei
- Email: rominabelenmattei@gmail.com
- Phone: +541140485216
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.