How EDOF lens implants change eye light sensitivity after presbyopic correction
Official title: Impact of Artificial Lighting on Visual Acuity After Presbyopia Correction With an Extended Depth of Focus Intraocular Lens: Introduction of a Modified Luminous Efficiency Function V(λ)'
Run by Democritus University of Thrace · NCT07077967 · Data updated 2026-11-12
This will test whether people aged 45–75 who had EDOF intraocular lens implants need different lighting levels to reach their best vision.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years to 75 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Democritus University of Thrace Academic / other |
| Locations | 1 site (Alexandroupoli, Evros) |
| Status | Recruiting |
| Started | October 15, 2025 |
| Main results expected | October 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT07077967 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 45–75 years old who have undergone pseudophakic presbyopic correction with EDOF IOLs, have postoperative uncorrected distance visual acuity of at least 8/10, and no major ocular or systemic exclusions listed in the protocol.
✕Probably not a fit
Patients with significant ocular disease (e.g., glaucoma, corneal or fundus disease), diabetes, autoimmune or neurological/psychiatric conditions, prior incisional eye surgery, astigmatism >1.00 D, posterior capsule rupture or lens misalignment are unlikely to benefit from the study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study measures how extended‑depth-of-focus (EDOF) intraocular lenses modify total eye light transmittance and the luminous efficiency function in pseudophakic patients treated for presbyopia. Participants who meet the inclusion and exclusion criteria will have their visual acuity tested at varying controlled light intensities to identify the minimum light level required to reach maximal acuity compared with full lighting. Findings will be used to model a modified luminous efficiency function specific to this patient group and to estimate task and environmental lighting adjustments. The study is conducted at the University Hospital of Alexandroupolis and enrolls patients aged 45–75 without major ocular or systemic comorbidities.
Why it matters
Potential benefit: If successful, the results could provide practical lighting recommendations to help people with EDOF IOLs achieve better everyday vision and comfort.
How similar studies have gone: Previous research has examined IOL effects on vision and light transmission in limited contexts, but a specifically modified luminous efficiency function for EDOF IOL patients is novel and not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 45 to 75 years Exclusion Criteria: * astigmatism \>1.00 diopters * glaucoma * former incisional eye surgery * corneal or fundus disease * diabetes mellitus * autoimmune diseases * neurological or psychiatric diseases * posterior capsule rupture or lens misalignment * postoperative uncorrected distance visual acuity \< 8/10.
Where it's running
-
University Hospital of Alexandroupolis
Alexandroupoli, Evros, Greece Recruiting
Study contacts
- Study coordinator: Eirini - Kanella Panagiotopoulou, MD, MSc, PhD
- Email: panagiotopoulou.ek@gmail.com
- Phone: +30 6978730858
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See if the Morrow eProgressive lenses work better than standard PALs for presbyopia
This study tests whether the electronically adjustable Morrow eProgressive lenses help people with presbyopia see and move more naturally compared with traditional progressive lenses.
-
Volumetric visual fields with occupational vs general-purpose progressive lenses in presbyopia
This study tests whether two occupational progressive lenses and a general-purpose PAL give different depth of clear vision at multiple distances for people with presbyopia.
-
Trying DAILIES TOTAL1 Multifocal Lenses in satisfied INFUSE wearers
This study tests whether switching satisfied INFUSE One-Day Multifocal wearers to DAILIES TOTAL1 Multifocal lenses maintains comfort and clear vision.
-
VisAbility Micro Insert System for Presbyopia
A new device called the VisAbility Micro Insert System is being tested to see if it can improve near vision at reading distance for adults with presbyopia.
-
Volumetric visual fields with progressive lenses for presbyopia at intermediate and near distances
Researchers will test two occupational progressive lenses to see which provides a larger clear field at intermediate and near distances for people with presbyopia.
-
Total30 Multifocal Toric Contact Lenses in Presbyopic Toric Wearers
This study tests whether Total30 MFT toric contact lenses are comfortable and acceptable for people who already wear reusable toric lenses and are now presbyopic.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.