How classroom indoor air affects children's allergies and wellbeing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will enroll children already in the SynAir-G observational cohort and classify them as cases or controls based on baseline questionnaire responses about asthma and allergic symptoms. Participants and caregivers will complete standardized questionnaires while children undergo skin prick allergy tests, non-invasive lung function tests, oxygen saturation checks, and provide biological samples as appropriate. Portable sensors placed in classrooms (and optionally at home) will continuously measure multiple air and dust pollutants to create individualized exposure baselines and detect changes over time. Health outcomes including respiratory symptoms, immune markers, and quality-of-life measures will be compared to the continuous exposure data to identify pollutant patterns associated with worsening or improvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Child included in the SynAir-G observational study
* Child and caregiver(s) willing to follow the study procedures
* Written informed consent from the child's parents/guardians
* For case group, at least one positive answer (yes) to any of the following questions and for control group, negative answers to all the following questions based on the baseline questionnaire administered in the SynAir-G observational study, as shown below.:

  a. General health i. Does your child have any health problems (if yes to asthma, allergic rhinitis /rhino-conjunctivitis, atopic dermatitis)? b. Asthma i. Has your child ever had wheezing or whistling in the chest in the past 12 months? ii. In the past 12 months, has your child's chest sounded wheezy during or after exercise? iii. In the past 12 months, has your child had a dry cough at night, apart from a cough associated with a cold or chest infection? c. Rhinitis i. In the past 12 months has your child had a problem with sneezing, or a runny, or blocked nose when she/he DID NOT have a cold or the flu? d. Eczema (both answers yes) i. Has your child had this itchy rash at any time in the past 12 months? If so, has this itchy rash at any time affected any of the following places: the folds of the elbows, behind the knees, in front of the ankles, under the buttocks, or around the neck, ears or eyes? e. Food allergy i. Has your child had diagnosed food allergy during last 12 months?
* For case group: Diagnosis of asthma/allergic rhinitis/eczema/food allergy (based on SYNAIR-G baseline questionnaire), active during the past year.
* For control group: absence of diagnosis of asthma/allergic rhinitis/eczema/food allergy (based on SYNAIR-G baseline questionnaire)

Exclusion Criteria:

* Child or child's parents/guardians who:

  1. Refuse to participate in the project / to give informed consent.
  2. Do not want to follow the protocol procedures.
  3. Do not read or/and write in French.
  4. Plan a long stay outside the region that does not allow them to follow the visit plan.
  5. The child is not affiliated to the French social security service

Where it's running

• CHU Montpellier
  Montpellier, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.