How braces affect the mouth microbiome and saliva proteins in teens

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will recruit 8- to 18-year-olds undergoing orthodontic treatment at the Stomatology Hospital of Xi'an Jiaotong University. Baseline oral health data, oral hygiene, caries risk, and questionnaires will be collected before treatment, and plaque and saliva samples will be gathered at regular intervals during treatment. The goal is to characterize how orthodontic care influences oral microbiota and salivary proteins across the course of treatment. No experimental interventions are performed; participants provide samples and complete follow-up assessments to track natural changes associated with orthodontic care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* No carries and White spot
* No missing teeth
* No history of oral treatment
* No malocclusion
* No systemic diseases

Exclusion Criteria:

* Antibiotic use in the past three months
* A history of long-term medication use
* A history of dental fillings
* Unable to attend regular follow-ups

Where it's running

• tomatology Hospital of Xi'an Jiaotong University,
  Xi'an, Shaanxi, China Recruiting

Study contacts

• Study coordinator: Shanshan Dai
• Email: daishanshan0723@163.com
• Phone: 86+15319976663

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Powered vs Manual Toothbrushes for Kids: Does it affect Cavity Risk?

  This study tests whether using a powered toothbrush twice daily for a year lowers cavity risk in kids aged 8–12 compared with a standard manual brush, using fluoride toothpaste as the control.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07859553

• Biomin fluoride varnish vs. Duraphat, with or without diode laser, for white spot lesions in primary teeth

  This trial tests whether Biomin fluoride varnish, alone or with diode laser, can better remineralize white spot lesions in young children than standard Duraphat varnish.

  Recruiting at 2 sites Alexandria University · Alexandria, Alexandria Governorate and 1 other locations · NCT07845110

• Epinamel Gel for Rebuilding White Spot Lesions Around Braces

  A gel called Epinamel is being tested to see if it can help white spot lesions around braces regain enamel strength and appearance in teens and adults.

  Recruiting Mintech Bio Ltd · London · NCT07730359

• AI-supported child-friendly communication to reduce dental anxiety during local anesthesia in children

  This compares AI-assisted child-friendly communication with traditional behavior techniques to see if it reduces anxiety, stress, and pain during local anesthesia in children aged 6–12.

  Recruiting Çanakkale Onsekiz Mart University · Çanakkale, Kepez · NCT07133919

• 2% Calcium Hypophosphite Toothpaste versus 1450 ppm Fluoride Toothpaste for Preventing Cavities

  This will test whether a toothpaste containing 2% calcium hypophosphite prevents cavities as well as a standard 1450 ppm fluoride toothpaste in people with at least 10 healthy molars and premolars.

  Recruiting Dr. Kurt Wolff GmbH & Co. KG · Bialystok, Poland and 1 other locations · NCT07068204

• Using specialized MRI for dental imaging

  This study is testing a new type of MRI specifically for dental imaging to see if it can better diagnose dental problems compared to regular imaging methods.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06948162

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.