How blood flow changes after flow-diverter treatment for brain aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective cohort follows adults with intracranial aneurysms treated with flow diverters using 3D digital subtraction angiography (3D-DSA) and transcranial color-coded duplex (TCCD) sonography to measure hemodynamic changes. Patients undergo baseline and follow-up DSA (at least 1 month) and serial TCCD to detect and quantify in-stent stenosis and associated flow alterations. The team aims to determine whether specific blood-flow values predict the development or severity of in-stent narrowing. Cases with secondary aneurysms, prior surgical/endovascular repair, or aneurysm locations not accessible to TCCD are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age ≥ 18, male or non-pregnant female. Diagnosis of intracranial aneurysm confirmed by DSA (Digital Subtraction Angiography).

Intracranial aneurysms treated with flow diverter (FD). DSA follow-up of at least 1 month.

Exclusion Criteria:

Secondary intracranial aneurysm cases: traumatic aneurysms, infectious aneurysms, or aneurysms associated with arteriovenous malformations (AVM) or vasculitis.

Previously treated recurrent aneurysm or target aneurysm with craniotomy clipping surgery or other endovascular interventions.

Aneurysms located at the distal end of the circle of Willis where TCCD (Transcranial Color-Coded Doppler) cannot be detected.

Known familial clustering history. Expected survival less than 1 year. Preoperative clinical assessment with mRS (Modified Rankin Scale) score ≥ 3. Known allergy or contraindication to antiplatelet drugs, anticoagulants, contrast agents, anesthetics, nitinol memory alloy, platinum-tungsten alloy, or platinum-iridium alloy.

Severe respiratory, hepatic, or renal disease (e.g., creatinine ≥ 3.0 mg/dL excluding dialysis) or coagulation disorders.

Undergoing major surgery (e.g., limb fracture fixation, tumor resection, major organ surgery, etc.) within 30 days prior to signing informed consent or planned within 60 days after signing informed consent.

Pregnant or lactating women, or women with a positive pregnancy test.

Where it's running

• DuanChuanzhi
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Duan Chuan zhi, MD — Study Principal Investigator
• Study coordinator: Zhang Xin, MD
• Email: zhangxin19830818@163.com
• Phone: 15989058895

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating the DERIVO® 2heal® Embolisation Device for treating intracranial aneurysms

  This study is testing a new device to see if it safely and effectively treats brain aneurysms in patients over a three-year period.

  Recruiting at 17 sites Acandis GmbH · Augsburg and 16 other locations · NCT05543447

• Flow Diverter Stent for Intracranial Aneurysm in China

  This study tests a novel flow diverter stent to treat intracranial aneurysms in adults and follows patients through treatment and follow-up.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07821957

• Surface-modified Flow Diverters for Unruptured Intracranial Aneurysms

  This study tests two surface-modified flow diverters, PED Shield and LFD, to see which better lowers ischemic complications in adults with unruptured intracranial aneurysms.

  Recruiting Henan Provincial People's Hospital · Zhengzhou, Henan · NCT07674004

• Real-World Experience With the WEB Device for Intracranial Aneurysms

  This study tests how well the Woven EndoBridge device works in routine treatment of intracranial aneurysms in China across multiple centers.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT07620626

• Heart rhythm and blood flow changes during pregnancy and after birth

  This project will test whether measuring heart rate variability and blood pressure can track heart and circulation changes in pregnant people from the third month through the postpartum period.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo, Pontevedra · NCT07376616

• Virtual reality versus IV dexmedetomidine to reduce maternal anxiety during cesarean delivery

  This study will test whether virtual reality or an IV dexmedetomidine infusion better reduces anxiety, stabilizes blood pressure and heart rate, and improves newborn breathing and heart rate in women having elective cesarean delivery under neuraxial anesthesia.

  Recruiting Benha University · Banhā, Benha · NCT07343843

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.