How alcohol, drugs, and pain medicines affect evaluation after a stab or gunshot to the belly
Official title: Influence of Alcohol, Psychoactive Drugs, and Analgesic Administration on the Evaluation Process in Patients With Penetrating Abdominal Trauma
Run by Fundacion Clinica Valle del Lili · NCT07330349 · Data updated 2026-11-12
This study will see if alcohol, psychoactive drugs, or pain medicines change how doctors evaluate and decide on surgery for people with penetrating abdominal injuries.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 15 Years and up |
| Sex | All |
| Enrollment | 363 (estimated) |
| Sponsor | Fundacion Clinica Valle del Lili Academic / other |
| Locations | 2 sites (Cali, Valle del Cauca Department and 1 other locations) |
| Status | Recruiting |
| Started | November 25, 2020 |
| Main results expected | December 24, 2025 |
| Study ends | January 30, 2026 |
| Registry record updated | January 9, 2026 |
| Trial ID | NCT07330349 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 14 or older who present with penetrating abdominal trauma and are hemodynamically stable at one of the participating centers.
✕Probably not a fit
Patients who are hemodynamically unstable, transferred after an initial operation, declared dead on arrival, or who lack sufficient clinical data are unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort enrolling patients aged 14 and older with penetrating abdominal trauma who are hemodynamically stable at two level I trauma centers in Cali, Colombia. Participants receive routine care with serial abdominal physical examinations and selective use of FAST or CT as indicated, while the team records whether alcohol, psychoactive substances, or analgesics were present before or during initial evaluation. The main analyses compare time from admission to surgical decision, use of diagnostic imaging, and rates of non-therapeutic laparotomy between exposed and unexposed patients. No additional diagnostic or therapeutic interventions are performed for study purposes; exposures are identified from clinical assessment and chart review using predefined definitions.
Why it matters
Potential benefit: If successful, the findings could help clinicians know when serial physical exams are reliable and reduce unnecessary imaging, delays to surgery, or non-therapeutic operations.
How similar studies have gone: Existing evidence is limited and mixed, with few prospective data, so this observational approach addresses a relatively under-studied question in trauma care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting to the emergency department with penetrating abdominal trauma. * Age 14 years or older. * Patients evaluated and managed according to standard trauma care protocols, including immediate operative management or clinical observation with serial physical examination, as clinically indicated. * Patients admitted to the participating trauma centers during the study period. Exclusion Criteria: * Patients transferred from another institution after initial surgical intervention. * Patients declared dead on arrival. * Patients with incomplete or missing clinical data precluding assessment of outcomes of interest.
Where it's running
-
Fundación Valle del Lili
Cali, Valle del Cauca Department, Colombia Recruiting -
Hospital Universitario del Valle Evaristo García
Cali, Valle del Cauca Department, Colombia Recruiting
Study contacts
- Study coordinator: Sergio I Prada Ríos, PhD
- Email: sergio.prada@fvl.org.co
- Phone: +57 6023319090
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Predictors of In-Hospital Death in Severe Abdominal Injury
This study will follow adults with severe abdominal trauma at a large Egyptian hospital to see which factors best predict in-hospital death.
-
Ketogenic Diet and Alcohol Intoxication: Can ketosis affect brain function and alcohol response
This study tests whether a 4‑week ketogenic diet changes how the brain works and how the body handles alcohol in adults who drink regularly.
-
Bringing Just Care for Families to rural Oregon with a mobile app and trained local Experts
This trial will test whether adding a mobile app and local Expert coaching helps parents with opioid or stimulant use who are involved with child welfare get more treatment and improve family outcomes.
-
How alcohol changes the social brain during paired interactions
This study tests whether drinking alcohol changes brain activity and social bonding during conversations between pairs of regular social drinkers aged 21–30.
-
Tech-assisted relapse prevention for substance use disorders
A digital monitoring tool is being tested to see if it helps people with substance use disorders stay in recovery longer when added to standard multidisciplinary treatment.
-
Comparing two therapies for alcohol addiction
This study is testing which therapy, Combined Behavioral Intervention or Ericksonian Hypnotherapy, works better to help adults with alcohol addiction reduce their drinking and improve their overall well-being.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.