How a 30-minute run changes appetite during short-term calorie restriction
Official title: Acute Effect of Exercise on Appetite, Appetite-Regulatory Hormones, and Energy Intake During Energy Restriction in Healthy Men
Run by University of Glasgow · NCT06895837 · Data updated 2026-11-12
This research will test whether a 30-minute bout of treadmill exercise changes hunger, appetite-related hormones, and how much healthy men eat while on a short-term calorie-restricted diet.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Men only |
| Enrollment | 14 (estimated) |
| Sponsor | University of Glasgow Academic / other |
| Locations | 1 site (Glasgow) |
| Status | Recruiting |
| Started | July 30, 2025 |
| Main results expected | April 30, 2028 |
| Study ends | April 30, 2028 |
| Registry record updated | January 7, 2026 |
| Trial ID | NCT06895837 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy men aged 18–65 with stable body weight (±2 kg for at least six months), not on special diets, nonsmokers, free of metabolic or mental-health conditions, not taking medications, and able to safely perform treadmill running.
✕Probably not a fit
Women, people outside the 18–65 age range, those with metabolic disease, on medications, smokers, on special diets, with food allergies, or with contraindications to running are not eligible and would not benefit from the results directly.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy men are screened, measured for body composition, and complete two treadmill tests to determine aerobic capacity (V̇O2max). Each participant completes three 24-hour laboratory visits in a counterbalanced order: a control day at full energy intake, a severe-energy-restriction day, and a severe-energy-restriction day that includes a 30-minute run at ~75% V̇O2peak. Appetite ratings, blood samples for appetite-regulatory hormones, and an ad libitum meal to measure energy intake are collected during each visit. All visits start after an overnight fast and use prescribed evening meals to standardize prior intake.
Why it matters
Potential benefit: If successful, the findings could offer a simple exercise strategy to help men manage hunger and food intake during short-term dieting.
How similar studies have gone: Previous short-term studies have shown that acute exercise can transiently suppress appetite and alter appetite hormones, but results are mixed and evidence is limited for severe energy restriction scenarios.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males aged 18 years or older. * Have stable body mass for at least six months (within ±2 kg). Exclusion Criteria: * Females * People who are younger than 18 or older than 65 years old. * Following a special diet (e.g. weight loss, vegetarian or vegan, etc.). * Have food allergies related to the study. * Have significant contraindications to exercise (e.g., an injury that would inhibit running). * Smoking. * Taking any medications. * Suffering from metabolic health issues, e.g., history of diabetes, cardiovascular disease, or eating disorders. * Have any mental health conditions.
Where it's running
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New Lister Building, Glasgow Royal Infirmary
Glasgow, United Kingdom Recruiting
Study contacts
- Principal investigator: James Dorling, PhD — University of Glasgow
- Study coordinator: Sultan Alenezi, MSc
- Email: a.sultan-kheneisr-w.1@research.gla.ac.uk
- Phone: +44 778 653 0734
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.