Home semen testing for men starting to conceive

Randomized Controlled Trial of Home Semen Testing in Men Beginning Attempts to Conceive

Not applicable Interventional Northwestern University · NCT05503862

This study is testing a home semen testing kit to see if it can help couples trying to conceive by making it easier to check for male infertility.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages18 Years and up
SexMale
SponsorNorthwestern University Academic / other
Drugs / interventionschemotherapy
Locations1 site (Chicago, Illinois)
Trial IDNCT05503862 on ClinicalTrials.gov

What this trial studies

This study aims to improve early detection of male factor infertility by implementing a universal screening model using home semen testing. It focuses on assessing the feasibility and utility of this testing method for couples who are beginning their attempts to conceive. Participants will complete home semen tests to evaluate ease of use and identify any obstacles they may encounter. The goal is to reduce fertility-related anxiety and expedite evaluation and treatment for couples while minimizing unnecessary costs and health issues.

Who should consider this trial

Good fit: Ideal candidates are natal males over 18 years old, without prior children, who are interested in future fertility and have a current female partner.

Not a fit: Patients with a history of male infertility or those whose female partners have a history of infertility may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to earlier detection of male infertility, reducing anxiety and improving treatment outcomes for couples trying to conceive.

How similar studies have performed: While the concept of home semen testing is relatively novel, similar approaches in fertility evaluation have shown promise in enhancing patient engagement and early detection.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Natal males over the age of 18 with no prior children who are interested in future fertility
* Current female partner
* Not attempting to conceive for more than 3 months
* Willing to sign the Informed Consent Form
* Able to read, understand, and complete patient questionnaires, pain texts, and medication diary.
* Ownership or accessibility of a smart phone or electronic device that is compatible with the YoSperm® device

Exclusion Criteria

* Prior semen testing
* History of male infertility, Klinefelter syndrome, undescended testis, or chemotherapy
* Female partner with history of infertility
* Female partner with irregular menstrual periods

Where this trial is running

Chicago, Illinois

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Male Infertility
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.