Home-based exercise program for women recovering from endometrial cancer
The Effect of Combined Aerobic and Muscle Strengthening Exercises on Structural and Functional Cardiovascular Adaptations in Endometrial Cancer Survivors
This study is testing a home exercise program to see if it helps women recovering from endometrial cancer get fitter and improve their heart health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 33 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Trial ID | NCT06534008 on ClinicalTrials.gov |
What this trial studies
STRIVE Cardio is a 12-week home-based exercise intervention designed for women who have completed treatment for non-metastatic endometrial cancer within the last five years and are currently in remission. The program includes a combination of in-person assessments, virtual health coaching, and the provision of exercise equipment such as resistance bands and a Fitbit. Participants will engage in a structured exercise regimen while receiving support and feedback to enhance their fitness and cardiovascular health. The study aims to measure improvements in functional fitness and cardiovascular metrics through various assessments.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 and older who have been diagnosed with stage I-IIIc endometrial cancer and have completed their treatment within the last five years.
Not a fit: Patients with absolute contraindications to exercise or a history of significant heart disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly enhance the physical fitness and cardiovascular health of endometrial cancer survivors.
How similar studies have performed: Other studies have shown success with similar home-based exercise interventions for cancer survivors, indicating potential for positive outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Willing and able to provide written informed consent * Willing to comply with study procedures and available for the duration of the study * Fluent in spoken and written English * Women 18 years of age or older * Documented diagnosis of Type I, stage I-IIIc endometrial cancer within the past 5 years * Completion of current cytotoxic treatment for endometrial cancer * Technology access (phone call access, broadband internet, Wi-Fi) for tele coaching * Comfort and willingness to use technology (videoconferencing) throughout the study for coaching * Pass the Physical Activity Readiness Questionnaire (PAR-Q) * Medical clearances given by their primary provider / oncologist (if indicated by the PAR-Q) Exclusion Criteria * Absolute contraindications to exercise (i.e., acute myocardial infarction, severe orthopedic or musculoskeletal limitations) * History of previous myocardial infarction, ischemia, or hemorrhagic stroke * Medically documented history of heart disease including heart valve disease, coronary artery disease, heart failure, peripheral artery disease, aortic disease, pericardial disease, cerebrovascular disease, or deep vein thrombosis * Medical documentation of treatment-resistant hypertension OR taking ≥2 medications to treat hypertension * Medically documented history of cardiovascular disease including (but not limited to): bypass surgery, stent procedures, bypass grafts, or coronary angioplasty * Medically documented or self-reported type 1 diabetes (insulin-dependents) * Prescriptions for or use of semaglutide (GLP-1 agonists) including name brands: Ozempic, Wegovy or Mounjaro * Current or recent (within last 3 months) use of hormone replacement therapy (HRT) * Evidence of recurrent or metastatic disease * Currently performing resistance training ≥2 days per week * Currently exceeding 150 minutes of at least moderate intensity exercise per week * Report of chest pain, shortness of breath, fainting, or angina pectoris * Self-reported history of falling, fall risk * Have physical disability that would limit range of motion through exercises such as sitting, standing and inability to walk one block * Plans to move from the area * Enrolled in another clinical trial or has used of any investigational drugs, biologics, or devices within 30 days prior to study enrollment * Self-reported tobacco use in last 7 days, current smoking, current tobacco use including e-cigarettes and vaping devices * Not suitable for study participation due to other reasons at the discretion of the investigator
Where this trial is running
Iowa City, Iowa
- University of Iowa — Iowa City, Iowa, United States (Recruiting)
Study contacts
- Principal investigator: Jess Gorzelitz, PHD, MS — University of Iowa
- Study coordinator: Jess Gorzelitz, PHD, MS
- Email: jessica-gorzelitz@uiowa.edu
- Phone: 3194670849
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.