Home Ammonia Monitoring for People with Metabolic Ammonia Disorders
Official title: Pilot Study of At Home Ammonia Monitoring in Patients With an Inborn Error of Ammonia Metabolism
Run by Sequitur Health Corp. · NCT06953505 · Data updated 2026-11-12
This study tests whether people with certain ammonia metabolism disorders can successfully measure their ammonia levels at home every day.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Sequitur Health Corp. Industry-sponsored |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | September 23, 2025 |
| Main results expected | July 2027 |
| Study ends | August 2027 |
| Registry record updated | May 27, 2026 |
| Trial ID | NCT06953505 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking individuals with a confirmed ammonia metabolism disorder and the ability to read in English.
✕Probably not a fit
Patients without access to at-home monitoring devices or those unable to perform daily measurements may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study aims to determine if patients with inherited ammonia metabolism disorders can perform daily home ammonia monitoring. Participants will visit the clinic twice and use a device to measure daily ammonia, along with daily vital signs and a short survey. The study will also collect information on how feasible and acceptable home monitoring is for these patients. The approach relies on at-home measurements to understand real-world adherence and data quality in everyday settings. The study leverages collaboration between Sequitur Health, NICHD, and Oregon Health & Science University.
Why it matters
Potential benefit: If successful, patients could benefit from easier, near-real-time monitoring of ammonia levels that may inform treatment decisions.
How similar studies have gone: Previous efforts in home biomonitoring for metabolic conditions have shown mixed feasibility, with ongoing evaluation of adherence and data reliability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed ammonia disorder such as * Ornithine transcarbamylase deficiency * Systemic primary carnitine deficiency * Type I citrullinemia * Argininosuccinic aciduria * Isolated methylmalonic acidemia * Type II citrullinemia * Propionic acidemia * Isovaleric acidemia * Multiple acyl-CoA dehydrogenase deficiency * Pyruvate carboxylase deficiency * Argininemia (arginase deficiency) * Carbamoyl phosphate synthase I deficiency * Dihydrolipoamide dehydrogenase deficiency * Lysinuric protein intolerance * Hyperornithinemia-hyperammonemia-homocitrullinuria * Carnitine-acylcarnitine translocase deficiency * Carbonic anhydrase VA deficiency * N-acetyl glutamate synthetase deficiency * English Literacy Exclusion Criteria: * Incarcerated * Presence of a non-inborn error of metabolism medical condition associated with abnormal ammonia metabolism (e.g., end stage liver disease). * Unable to read in English
Where it's running
-
Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: Marylaura L Thomas, Ph.D. — Sequitur Health Corp.
- Study coordinator: Marylaura Thomas, Ph.D.
- Email: info@sequiturhealth.com
- Phone: 1-855-445-3889
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.