Holographic Low-Intensity Focused Ultrasound for Anxiety

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial uses a cross-over design to compare real versus sham LIFU sessions, with multiple weeks of follow-up that include MRI scans and anxiety assessments. A custom hologram-based approach lenses the ultrasound waveform to target brain regions. Pre- and post-stimulation anxiety measurements are collected using the NPU task and standard questionnaires at each visit. The study aims to determine if repeated, patient-specific LIFU treatment can produce measurable improvements in anxiety-related outcomes compared with sham stimulation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with generalized anxiety disorder (GAD) symptoms; defined by a GAD-7 score \>= 10, OASIS score \>= 8, or a PSWQ score \>= 45.

Exclusion Criteria:

* Claustrophobia
* Contraindications to MRI (certain implants or metal in the body)
* Contraindications to CT (pregnancy)
* Active medical disorder with CNS effects (e.g. Alzheimer's)
* History of neurological disorder
* History of head injury
* Active alcohol or drug dependence

Where it's running

• Fralin Biomedical Research Institute at VTC
  Roanoke, Virginia, United States Recruiting

Study contacts

• Study coordinator: Jessica Research Associate, MPH
• Email: jnw@vtc.vt.edu
• Phone: 540-526-2261

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.