High PEEP during noninvasive ventilation for hypoxemic respiratory failure
Official title: A Physiological Study of High PEEP During Noninvasive Ventilation in Patients With Hypoxemic Respiratory Failure
Run by Chongqing Medical University · NCT07503509 · Data updated 2026-11-12
This project will test whether higher PEEP settings on noninvasive ventilators help adults with hypoxemic respiratory failure improve oxygen levels.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Status | Recruiting |
| Started | March 26, 2024 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | March 31, 2026 |
| Trial ID | NCT07503509 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with hypoxemic respiratory failure (PaO2/FiO2 ≤ 300 and PaCO2 ≤ 50 mmHg) who are receiving noninvasive ventilation on a device that supports esophageal pressure monitoring and who do not have heart-failure‑driven respiratory failure, asthma, acute COPD exacerbation, or pneumothorax.
✕Probably not a fit
Patients whose respiratory failure is primarily due to heart failure, asthma, or acute COPD exacerbation, those with pneumothorax, or those unable or unwilling to undergo noninvasive ventilation with esophageal pressure monitoring are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional protocol applies higher positive end-expiratory pressure (PEEP) during noninvasive ventilation in adults with hypoxemic respiratory failure and records physiological responses. Eligible participants have PaO2/FiO2 ≤ 300 and PaCO2 ≤ 50 mmHg and must be managed on a noninvasive ventilator capable of esophageal pressure monitoring. The team will adjust PEEP levels while measuring esophageal pressures and gas exchange to clarify mechanisms by which high PEEP may improve oxygenation. The single-center trial is conducted at The First Affiliated Hospital of Chongqing Medical University and excludes patients with heart-failure‑driven respiratory failure, asthma, acute COPD exacerbation, or pneumothorax.
Why it matters
Potential benefit: If successful, this could identify NIV PEEP settings that improve oxygenation and potentially reduce the need for intubation in hypoxemic respiratory failure.
How similar studies have gone: Higher PEEP has improved oxygenation in invasively ventilated ARDS patients, but the physiological effects of high PEEP during noninvasive ventilation are less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. PaCO₂ ≤ 50 mmHg 3. PaO₂/FiO₂ ≤ 300 mmHg 4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) - Exclusion Criteria: 1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included) 2. Pneumothorax 3. Patients who refuse to participate in this trial -
Where it's running
-
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China Recruiting
Study contacts
- Principal investigator: Jun Duan, MD — First Affiliated Hospital of Chongqing Medical University
- Study coordinator: Jun Duan
- Email: duanjun412589@163.com
- Phone: +86-89012680
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Best starting flow for high-flow nasal cannula after extubation
This trial tests four different ways of setting the initial flow on high-flow nasal cannula to see if one approach reduces breathing problems or the need to be put back on a ventilator after adults are extubated.
-
Acupoint plaster added to standard anti-nausea medicine for lung cancer patients on platinum chemotherapy
This trial tests whether adding acupoint plaster to regular anti-nausea meds helps control chemotherapy-induced nausea and vomiting in adults with lung cancer receiving first-line platinum-based therapy.
-
Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism
In people with primary aldosteronism, this study tests whether aiming for a systolic BP under 120 mmHg is better than under 140 mmHg for lowering cardiovascular risk.
-
Ultrasound-guided nerve hydrodissection for diabetic leg nerves
A single ultrasound-guided nerve hydrodissection procedure is tested to see if it helps people with diabetic lower limb entrapment neuropathy feel less pain and have better nerve function.
-
Shortwave therapy for diabetic peripheral neuropathy
A one-center study will test whether shortwave therapy given for five days can improve nerve symptoms in adults with diabetic neuropathy compared to a sham treatment.
-
Environmental and inflammatory links to metabolic and endocrine diseases
This project will see if combining environmental, genetic, and protein information can help predict early risk of diabetes, hypertension, and other metabolic or endocrine problems in community adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.