High-Intensity Interval Training in Low vs Normal Oxygen for Overweight Adults Aged 50–75

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 50–75 with overweight or obesity will be assigned to HIIT sessions performed in hypoxic or normoxic conditions to measure effects on fat mass, including abdominal and visceral fat, and gut-related health markers. The trial compares two exercise environments to see if reduced oxygen during training offers additional benefits beyond standard HIIT. Participants must meet age, BMI, and health criteria and commit to a stable routine before and during the study. Outcomes will include changes in body composition and surrogate gut-health indicators collected through validated methods. The study is sponsored by a French metabolic-exercise research group and conducted at CREPS Auvergne-Rhône-Alpes in Vichy, France, with collaboration from AURA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Aged 50-75 years, inclusive Male or postmenopausal female, defined as no menstruation during the previous 12 months Body mass index between 25 and 35 kg/m², inclusive Non-smoker or smoking no more than two cigarettes per day Stable body weight for at least three months before study initiation, defined as a change of less than 4 kg Stable dietary habits and physical activity level for at least three months before study initiation Willing to maintain usual dietary habits and physical activity level throughout the study Able and willing to comply with the study protocol Able and willing to provide written informed consent Affiliated with a social security scheme Willing to be registered in the French National Register of Volunteers Participating in Biomedical Research

Exclusion Criteria:

Medical or surgical history considered by the investigators to be incompatible with participation in the study Any medical condition considered by the investigators to be incompatible with participation in the study Medical contraindication to vigorous physical activity Current use of hormone replacement therapy Current use of beta-blocker therapy Diagnosed moderate-to-severe sleep apnoea syndrome that is untreated or inadequately controlled High-risk cardiovascular history, including symptomatic coronary artery disease, recent myocardial infarction or stroke, unstable heart failure, clinically significant arrhythmia, or uncontrolled hypertension Severe respiratory disease, including advanced chronic obstructive pulmonary disease classified as group B or E according to the 2023 GOLD classification, chronic respiratory failure, or uncontrolled asthma Diabetes of any type Chronic kidney disease stage 3B, 4 or 5 according to the KDIGO classification Severe liver disease, defined by an international normalised ratio greater than 1.2-1.3 Antibiotic treatment during the three months preceding the first stool collection More than eight hours of moderate-to-vigorous physical activity per week Any treatment that, in the investigators' opinion, could interfere with assessment of the study outcomes Low-energy diet during the three months preceding the study or intention to begin an energy-restricted diet during the study Extreme dietary habits Stay at an altitude above 2,500 m for more than eight days during the three months preceding the study Participation in another clinical study or currently within an exclusion period following participation in a previous clinical study Total compensation received for participation in research since the beginning of the calendar year exceeding €4,500, or the applicable regulatory limit Linguistic or psychological inability to provide informed consent Refusal to provide written informed consent Legally protected adult Deprived of liberty by an administrative or judicial decision Under guardianship or curatorship

Where it's running

• CREPS Auvergne Rhône-Alpes / Vichy
  Bellerive-sur-Allier, France Recruiting

Study contacts

• Study coordinator: Nathalie BOISSEAU, Professor
• Email: nathalie.boisseau@uca.fr
• Phone: +33684331693

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.