High-intensity interval exercise to improve vitamin D levels in adults with overweight or obesity
Official title: The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity
Run by University of Thessaly · NCT07300332 · Data updated 2026-11-12
This trial will try three hybrid high-intensity interval sessions per week for 12 weeks to see if exercise increases vitamin D (25(OH)D) in adults with overweight or obesity during winter.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 35 Years to 50 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Thessaly Academic / other |
| Locations | 1 site (Trikala, Karyes) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | January 31, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07300332 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with BMI 25–35 kg/m2 who are non-smokers, free of musculoskeletal injuries and chronic health complications, and not taking vitamin D supplements, statins, steroids, or chronic anti-inflammatory drugs are ideal candidates.
✕Probably not a fit
People taking vitamin D supplements, smokers, those with BMI outside 25–35 kg/m2, with chronic health conditions, or who cannot safely perform high-intensity exercise are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Thirty adults with BMI 25–35 kg/m2 will be randomly assigned to an Exercise group or a Control group. The Exercise group will perform three supervised hybrid high-intensity interval training sessions per week for 12 weeks while following a balanced diet; the Control group will follow the same balanced diet but not perform the exercise program. Both groups will have resting blood draws for 25-hydroxyvitamin D, body composition measured by bioelectrical impedance, 24-hour dietary recalls, and physical activity monitored by accelerometry at baseline, 6 weeks, and 12 weeks. The study is conducted over winter at the University of Thessaly and excludes participants using vitamin D supplements or certain medications.
Why it matters
Potential benefit: If successful, this could offer a non-drug way to boost circulating vitamin D in adults with overweight or obesity, especially during months with low sun exposure.
How similar studies have gone: Previous studies showed that moderate-intensity cardiovascular exercise can blunt winter declines in 25(OH)D in adults with overweight/obesity, but the use of hybrid high-intensity interval training for this purpose is less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI = 25-35 kg/m2 * Absence of musculoskeletal injuries * Absence of chronic health-related complications * Non-smokers Exclusion Criteria: * Consumption of Vitamin D supplements * Consumption of anti-inflammatory drugs, statins and/or steroids
Where it's running
-
Department of Physical Education and Sport Science, University of Thessaly
Trikala, Karyes, Greece Recruiting
Study contacts
- Principal investigator: Dimitrios Draganidis, PhD — University of Thessaly
- Study coordinator: Dimitrios Draganidis, PhD
- Email: ddraganidis@uth.gr
- Phone: +302431047078
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.