Clinical trial Recruiting at 1 site Interventional Ages 35 to 50

High-intensity interval exercise to improve vitamin D levels in adults with overweight or obesity

Official title: The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity

Run by University of Thessaly · NCT07300332 · Data updated 2026-11-12

This trial will try three hybrid high-intensity interval sessions per week for 12 weeks to see if exercise increases vitamin D (25(OH)D) in adults with overweight or obesity during winter.

More Obesity & Overweight trials

Quick facts

Study typeInterventional
Ages35 Years to 50 Years
SexAll
Enrollment30 (estimated)
SponsorUniversity of Thessaly
Academic / other
Locations1 site (Trikala, Karyes)
StatusRecruiting
StartedNovember 1, 2025
Main results expectedJanuary 31, 2026
Study endsDecember 15, 2026
Registry record updatedNovember 6, 2026
Trial IDNCT07300332 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with BMI 25–35 kg/m2 who are non-smokers, free of musculoskeletal injuries and chronic health complications, and not taking vitamin D supplements, statins, steroids, or chronic anti-inflammatory drugs are ideal candidates.

Probably not a fit

People taking vitamin D supplements, smokers, those with BMI outside 25–35 kg/m2, with chronic health conditions, or who cannot safely perform high-intensity exercise are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thirty adults with BMI 25–35 kg/m2 will be randomly assigned to an Exercise group or a Control group. The Exercise group will perform three supervised hybrid high-intensity interval training sessions per week for 12 weeks while following a balanced diet; the Control group will follow the same balanced diet but not perform the exercise program. Both groups will have resting blood draws for 25-hydroxyvitamin D, body composition measured by bioelectrical impedance, 24-hour dietary recalls, and physical activity monitored by accelerometry at baseline, 6 weeks, and 12 weeks. The study is conducted over winter at the University of Thessaly and excludes participants using vitamin D supplements or certain medications.

Why it matters

Potential benefit: If successful, this could offer a non-drug way to boost circulating vitamin D in adults with overweight or obesity, especially during months with low sun exposure.

How similar studies have gone: Previous studies showed that moderate-intensity cardiovascular exercise can blunt winter declines in 25(OH)D in adults with overweight/obesity, but the use of hybrid high-intensity interval training for this purpose is less well studied.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* BMI = 25-35 kg/m2
* Absence of musculoskeletal injuries
* Absence of chronic health-related complications
* Non-smokers

Exclusion Criteria:

* Consumption of Vitamin D supplements
* Consumption of anti-inflammatory drugs, statins and/or steroids

Where it's running

  • Department of Physical Education and Sport Science, University of Thessaly
    Trikala, Karyes, Greece
    Recruiting

Study contacts

  • Principal investigator: Dimitrios Draganidis, PhD — University of Thessaly
  • Study coordinator: Dimitrios Draganidis, PhD
  • Email: ddraganidis@uth.gr
  • Phone: +302431047078

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.