High-intensity exercise for better recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of high-intensity exercise (HIE) in improving functional outcomes for stroke patients during inpatient rehabilitation. A total of 36 participants will be randomly assigned to either a high-intensity or low-intensity exercise program for two weeks, with both groups receiving standard post-stroke physiotherapy. Outcomes will be measured by blinded therapists using various scales to assess functional independence, balance, mobility, and fatigue. The study aims to determine if HIE leads to better recovery compared to lower intensity exercises.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Admitted for acute ischaemic or haemorrhagic stroke and requiring inpatient rehabilitation for stroke
2. First-ever, single, unilateral stroke
3. Aged 21-99 years old
4. Able to walk 10m overground with minimal or moderate physical assistance
5. Cleared by physician to be medically stable to participate in high intensity exercise (HIE)
6. Participants have to be warded for inpatient rehabilitation for at least 10 consecutive weekdays

Exclusion Criteria:

1. Any central or peripheral nervous system or orthopedic injury that may limit ambulation or exercise
2. Uncontrolled cardiorespiratory disease
3. Inability to follow 3 steps commands
4. Patient unable to give consent for the study
5. Patient who is assessed unsuitable to don on the medical device fNIRS (eg patients who had undergone craniectomy and cranioplasty)

Where it's running

• Sengkang General Hospital
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Shi Min Mah
• Email: mah.shi.min@skh.com.sg
• Phone: +6598780173

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Stem cell therapy for chronic stroke recovery

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• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.