High-dose vitamin D followed by maintenance to reduce seizures, fatigue, and improve quality of life in adults with epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, interventional study gives participants a high-dose vitamin D pulse followed by maintenance dosing and compares outcomes to a placebo group. Adults aged 20 and older with refractory epilepsy and stable brain imaging are enrolled and followed over time. Main outcomes include seizure frequency, patient-reported fatigue, and standardized quality-of-life measures collected longitudinally. Clinical and safety data will be used to determine whether vitamin D supplementation has measurable benefits as an adjunct to usual epilepsy care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 20 or above (inclusive)
* Diagnosed patients (refractory epilepsy refers to those who have used more than two drugs, and each drug has reached the When epileptic seizures cannot be well controlled at standard reasonable treatment doses, it is called refractory epilepsy)
* There is no imaging evidence of persistence or expansion of brain damage in the past three years
* Subjects or family members (caregivers) can comply with the trial plan and take vitamin D patients

Exclusion Criteria:

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Where it's running

• National Cheng Kung University Hospital
  Tainan, Taiwan Recruiting

Study contacts

• Principal investigator: Chin-Wei Huang — National Cheng-Kung University Hospital
• Study coordinator: Shiue Yu Chen, Master
• Email: snow700709@gmail.com
• Phone: +886-0927291671

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.