High Dose Rate Brachytherapy for Prostate Cancer Recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the long-term effects of High Dose Rate (HDR) Brachytherapy in men experiencing isolated local relapses of prostate cancer after radical prostatectomy. The study will compare HDR Brachytherapy with conventional external irradiation to determine if it improves control rates and reduces complications. Participants will receive HDR Brachytherapy as part of their standard medical care, combined with external beam radiation and androgen deprivation therapy to optimize treatment outcomes. The approach utilizes advanced imaging techniques to precisely target the affected areas while minimizing damage to surrounding tissues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with increasing PSA after RP and clinical evidence of PET PSMA/Choline+ and MRI+ isolated prostatic bed relapse (IPBR) that is implantable via transperineal route . The IPBR should be visible on TRUS imaging to allow proper implant placement.
* Pathological confirmation is advised in all cases but it is not mandatory .
* Brachytherapy MRI-based dosimetry
* Patient written Informed Consent of the Institutional Review Board-approved protocol that discloses the investigational nature of the treatment as well as the available standard treatment options.

Exclusion Criteria:

* Distant Metastases
* Isolated nodal relapses
* Prior Irradiation to the IPBR area
* Multicentric IPBRs
* Life expectancy of less than 5 years or inability to tolerate and comply with an HDR procedure

Where it's running

• Clínica Universidad de Navarra
  Pamplona, Foral Community of Navarre, Spain Recruiting

Study contacts

• Principal investigator: Rafael Martínez-Monge, M.D. — Clinica Universidad de Navarra Cancer Center
• Study coordinator: Gabriel Canel, Ph.D.
• Email: gcanel@unav.es
• Phone: 948255400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.