High Definition Transcranial Direct Current Stimulation for Refractory Epilepsy
The Efficacy, Safety and Mechanism of High Definition Transcranial Direct Current Stimulation (HD-tDCS) in the Treatment of Refractory Epilepsy
NA · Anhui Medical University · NCT06241963
This study is testing if a new brain stimulation treatment can help people with hard-to-control epilepsy feel better and improve their condition.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Anhui Medical University (other) |
| Locations | 1 site (Hefei, Anhui) |
| Trial ID | NCT06241963 on ClinicalTrials.gov |
What this trial studies
This study evaluates the clinical effects and safety of high definition transcranial direct current stimulation (HD-tDCS) in patients with refractory epilepsy. Participants will undergo a medical evaluation and receive either bilateral active, unilateral active, or sham HD-tDCS treatment over a series of sessions. The treatment aims to analyze its therapeutic mechanism through clinical assessments and neuroimaging techniques. The study will involve at least 90 participants randomized into different treatment groups at Anhui Medical University.
Who should consider this trial
Good fit: Ideal candidates are right-handed individuals aged 18-50 with a clinical diagnosis of refractory epilepsy.
Not a fit: Patients with major neurological or mental illnesses, serious physical diseases, or contraindications for MRI or EEG may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new non-invasive option for managing refractory epilepsy.
How similar studies have performed: Other studies have shown promise with transcranial direct current stimulation approaches, but this specific application for refractory epilepsy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of refractory epilepsy * Right-handed and aged 18-50 years old and primary school education or above; * No major neurological or mental illness, no head injury, alcohol dependence or drug dependence; * During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes. Exclusion Criteria: * organic brain injury, neurological diseases or serious physical diseases; * Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies; * There are contraindications for MRI or EEG or transcranial magnetic stimulation.
Where this trial is running
Hefei, Anhui
- Anhui Medical University — Hefei, Anhui, China (RECRUITING)
Study contacts
- Study coordinator: Kai Wang, PhD
- Email: wangkai1964@126.com
- Phone: +86-0551-62923704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Transcranial Direct Current Stimulation, EEG, Functional Magnetic Resonance Imaging, Refractory Epilepsy, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation