Heparin-binding protein and lung edema in ICU patients
Heparin-binding Protein (HBP) and Lungedema in ICU Patients. Is There a Correlation Between HBP and Pulmonary Vascular Permeability? A Prospective Observational Study
This will test whether blood levels of heparin-binding protein relate to lung fluid and total fluid balance in adult ICU patients monitored with a PiCCO device.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Östersund) |
| Trial ID | NCT07434908 on ClinicalTrials.gov |
What this trial studies
This single-center observational cohort will enroll about 25 adult ICU patients who are monitored with a PiCCO hemodynamic surveillance device. Researchers will collect blood samples to measure heparin-binding protein (HBP) and record PiCCO-derived measures such as extravascular lung water (EVLW), pulmonary blood volume (PBV), and the pulmonary vascular permeability index (PVPI). They will also track patients' cumulative fluid balance and relevant clinical data. The study will analyze correlations between plasma HBP concentrations and measures of lung vascular permeability, lung water, and total fluid balance.
Who should consider this trial
Good fit: Adults (over 18) in the ICU who are being monitored with a PiCCO system and are not transferred from another ICU are ideal candidates.
Not a fit: Patients under 18, those not monitored with PiCCO, or patients transferred from another ICU would not be eligible and are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help clinicians use HBP levels to identify increased lung vascular permeability and guide fluid management in critically ill patients.
How similar studies have performed: Previous work has linked HBP to vascular leak in inflammatory states and PiCCO-derived PVPI is an established measure of lung permeability, but direct correlation of HBP with PiCCO measures is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \>18 years * Monitored with a PiCCO system Exclusion Criteria: • Patients transferred from another ICU
Where this trial is running
Östersund
- ICU — Östersund, Sweden (Recruiting)
Study contacts
- Study coordinator: Line Samuelsson, MD
- Email: line.samuelsson@regionjh.se
- Phone: 063153000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.