Hemoadsorption with the Jafron HA130 cartridge during hemodialysis for adults on maintenance dialysis with inflammation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thirty adults on maintenance hemodialysis with elevated CRP and/or IL-6 will receive hemoadsorption with a Jafron HA130 cartridge performed concurrently with their dialysis sessions. The intervention is scheduled three times per week in month 1, twice per week in month 2, and once per week in month 3. Inflammatory markers (CRP, IL-1, IL-6, IL-8, β2-microglobulin, free light chains), PTH, standard biochemistry, and complete blood counts will be measured at baseline and monthly. The single-center study is conducted at Botkin Hospital in Moscow and excludes patients on steroids, with prior transplant, cancer, pregnancy, or active infection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adequate dialysis defined by a KT/V index ≥ 1.4
2. No active inflammatory process or infection
3. Age ≥ 18 years
4. Receiving standard hemodialysis regimen three times weekly, at least 4 hours per session
5. Participants with elevated interleukin-6 (IL-6) and/or C-reactive protein (CRP) levels exceeding local laboratory reference values

Exclusion Criteria:

1. Current use of steroids or immunosuppressive therapy
2. History of kidney transplantation
3. Diagnosis of cancer
4. Pregnancy

Where it's running

• Botkin Hospital
  Moscow, Russia Recruiting

Study contacts

• Study coordinator: Evgeny V Shutov, PhD
• Email: shutov_e_v@mail.ru
• Phone: +79055251002

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.