Helping opioid-dependent mothers and their infants

Intervening With Opioid-Dependent Mothers Living in Poverty: Effects on Mothers' and Infants' Behavioral and Biological Regulation

Not applicable Interventional University of Delaware · NCT04454645

This study tests a new program to help opioid-dependent mothers improve their parenting skills and support their infants' development during pregnancy.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages18 Years to 70 Years
SexFemale
SponsorUniversity of Delaware Academic / other
Locations1 site (Newark, Delaware)
Trial IDNCT04454645 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of a modified intervention designed to improve parenting skills and infant development among opioid-dependent mothers receiving medication-assisted treatment. Pregnant women in their third trimester will be randomly assigned to either the modified Attachment and Biobehavioral Catch-Up (mABC) intervention or a control intervention. The study aims to enhance maternal sensitivity and nurturing behaviors, which are expected to lead to better outcomes for both mothers and their infants in terms of attachment and physiological regulation.

Who should consider this trial

Good fit: Ideal candidates for this study are opioid-dependent pregnant women in their third trimester who are receiving medication-assisted treatment.

Not a fit: Patients who are not opioid-dependent or who are not in the third trimester of pregnancy may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve parenting practices and developmental outcomes for infants born to opioid-dependent mothers.

How similar studies have performed: Other studies have shown promise in using similar interventions to improve parenting and child outcomes in at-risk populations, suggesting potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Opioid-dependent pregnant women in third trimester of pregnancy on medication-assisted treatment

Exclusion Criteria:

* None

Where this trial is running

Newark, Delaware

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Opioid DependenceParentingInfant Development
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.