Heart rate variability biofeedback for recovery after brain injury

A Randomized Controlled Trial of Heart Rate Variability Biofeedback Following Traumatic Brain Injury

Early Phase 1 Interventional Brigham Young University · NCT05913505

This study is testing if a heart rate biofeedback program can help people with mild brain injuries feel better and recover faster after stress.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 55 Years
SexAll
SponsorBrigham Young University Academic / other
Locations1 site (Provo, Utah)
Trial IDNCT05913505 on ClinicalTrials.gov

What this trial studies

This study investigates the effects of heart rate variability biofeedback on individuals with mild traumatic brain injury. Participants will be randomly assigned to either an active biofeedback condition aimed at increasing heart rate oscillations or a sham condition designed to decrease them. The study will measure changes in heart rate variability before and after a 5-week treatment period, as well as recovery following stressors. The goal is to determine if biofeedback can improve heart rate variability and associated physical symptoms in this population.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 18-55 who are at least six months post-injury and fluent in English.

Not a fit: Patients with a pacemaker, previous heart attacks, or other significant neurological conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could enhance recovery and reduce symptoms in patients with mild traumatic brain injury.

How similar studies have performed: While the specific approach of heart rate variability biofeedback in this context is novel, similar interventions have shown promise in other studies.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least six months post-injury to account for spontaneous recovery
* Aged 18-55 years
* Fluent in English
* Able to provide informed consent.

Exclusion Criteria:

* Presence of a pacemaker
* Previous self-reported heart attack with hospitalization
* Diagnosed learning disability
* Other neurological difficulties or diagnoses (i.e., stroke, epilepsy)
* Participation in current litigation
* Uncorrected visual impairment.

Where this trial is running

Provo, Utah

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Traumatic Brain Injury
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.