Heart monitoring for cancer patients receiving chemotherapy and targeted drugs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter observational effort to monitor cardiac outcomes in adults undergoing chemotherapy or molecularly targeted cancer therapies. Participants will undergo periodic cardiac evaluations including ECG, echocardiography, and biomarker testing (troponin T, NT‑proBNP), with blood samples collected for genomic analysis. Local factors (for example, central venous catheter–related thrombosis) and systemic factors (age, comorbidities, BMI, genetic variants) will be integrated to develop a predictive model for major adverse cardiovascular events (MACE). The study will also track the impact of cardiotoxicity and the monitoring strategy on patients' quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1.Adults (age \> 18 years) with a pathologically confirmed malignant tumor (any type of cancer); 2.Currently receiving or planning to receive chemotherapy (including regimens containing molecular targeted drugs) as adjuvant treatment for cancer; 3.Willing and able to participate in the study with provision of informed consent, and agreeable to provide required clinical data and biological samples.

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Exclusion Criteria:

1. Incomplete basic patient information or medical records (missing key data necessary for the study);
2. Failure to complete the full course of planned chemotherapy at the study center (e.g., patient did not adhere to or finish all cycles of adjuvant chemotherapy at our institution);
3. History of severe acute cardiovascular or cerebrovascular events within 6 months prior to enrollment, including acute heart failure, acute myocardial infarction, acute intracerebral hemorrhage (stroke), malignant arrhythmia, or New York Heart Association (NYHA) Class IV/V heart failure;
4. Missing essential pre- or post-chemotherapy evaluations: patients who did not undergo complete baseline or end-of-treatment assessments (such as blood routine, hepatic/renal function, coagulation profile, cardiac enzymes (troponin T), NT-proBNP (or BNP), 12-lead ECG, and echocardiogram)

Where it's running

• Sixth Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: xiaoyan li — Sixth Affiliated Hospital, Sun Yat-sen University
• Study coordinator: xiaoyan li
• Email: lixyan5@mail.sysu.edu.cn
• Phone: 13609066172

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.