Health effects of electronic cigarettes in smokers living with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the health effects of using electronic cigarettes (ECs) as an alternative to traditional cigarettes among HIV-positive smokers who are not ready to quit smoking. It aims to assess the feasibility and acceptability of distributing ECs, the impact of EC use on smoking behaviors, and changes in cardiopulmonary symptoms and biomarkers over a 12-week period. Participants will be randomly assigned to either receive ECs or continue smoking their usual brand, with regular monitoring of their health and smoking habits. The study will also provide resources for smoking cessation at the end of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosed with and engaged in care for HIV (defined as at least one HIV clinic medical appointment within the past six month period)
* at least 18 years of age
* smoke at least 5 cigarettes per day for longer than one year
* exhaled carbon monoxide (CO) level greater than 5 at BL

Exclusion Criteria:

* intention to quit smoking in the next 30 days
* currently using pharmacotherapy for smoking cessation
* currently using electronic cigarettes more than 2 days/week
* unstable medical or psychiatric condition (defined as hospitalization)
* medical contraindications to nicotine (unstable angina, uncontrolled hypertension, or recent cardiovascular event, including hospitalization)
* psychotic symptoms
* substance use disorder other than nicotine dependence
* past-month suicidal ideation or past-year suicide attempt
* pregnant or nursing.

Where it's running

• Brown University School of Public Health
  Providence, Rhode Island, United States Recruiting

Study contacts

• Principal investigator: PATRICIA A CIOE, PhD — Brown University
• Study coordinator: PATRICIA A CIOE, PhD
• Email: patricia_cioe@brown.edu
• Phone: 401-863-6638

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Project SHIELD 2.0: Police Education to Support Public Health in Kentucky

  Aimed at police in Kentucky, this program tests whether SHIELD training given to officers, with health workers helping deliver it, can reduce drug-related arrests and steer people who use drugs toward MOUD and other health services.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Lexington, Kentucky · NCT07804121

• New ways to diagnose lymphoma and multicentric Castleman disease in people living with HIV

  This study tests a quick, point-of-care nucleic acid test to help diagnose lymphoma and multicentric Castleman disease in people living with HIV in sub-Saharan Africa.

  Recruiting Indiana University · Lilongwe · NCT07793006

• Bridge to Belonging: A Peer‑Led Program to Reduce Loneliness and Depression in older gay and bisexual men with HIV

  This program tests a peer-delivered, manualized approach to help men aged 50+ with HIV connect to LGBTQ+-affirming elder services to see if it reduces loneliness and depressive symptoms.

  Recruiting Fenway Community Health · Boston, Massachusetts · NCT07762066

• HIV vaccine test in healthy adults using CH505 nanoparticles and mRNA boosters

  This early-stage study will test the safety and immune responses of CH505 vaccine regimens in healthy adults to see if they can trigger HIV-specific immune protection.

  Recruiting at 2 sites Phase 1 National Institute of Allergy and Infectious Diseases (NIAID) · San Francisco, California and 7 other locations · NCT07757802

• Stigma-reducing program to help women who use drugs stay in HIV care

  This test checks whether a stigma-reduction program helps women living with HIV who use drugs stay engaged in HIV care in Ukraine.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Kyiv, Kyiv Oblast · NCT07751978

• Platelets and HIV Reservoirs: A look at how platelets might harbor HIV in people living with HIV

  This observational study tests whether HIV can be found inside platelets in adults with suppressed HIV on therapy.

  Recruiting Tourcoing Hospital · Tourcoing · NCT07745530

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.