Clinical trial Recruiting at 1 site Observational Ages 40 to 100

Health economic burden of Alzheimer’s disease in China

Official title: The Alzheimer's Disease Burden in China (ABC) Study: a Nationwide Multicentre Cross-sectional and Prospective Cohort Study

Run by Xuanwu Hospital, Beijing · NCT05995418 · Data updated 2026-11-12

This study tests how Alzheimer’s disease and mild cognitive impairment affect costs and quality of life for patients and caregivers across China.

Quick facts

Study typeObservational
Ages40 Years to 100 Years
SexAll
Enrollment9510 (estimated)
SponsorXuanwu Hospital, Beijing
Academic / other
Locations1 site (Beijing)
StatusRecruiting
StartedJuly 1, 2023
Main results expectedJune 30, 2026
Study endsJanuary 1, 2027
Registry record updatedJune 5, 2026
Trial IDNCT05995418 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults diagnosed with Alzheimer’s disease or amnestic mild cognitive impairment (aMCI) meeting NIA-AA criteria and with CDR ≥ 0.5, who can participate in assessments and provide consent.

Probably not a fit

Patients with conditions that prevent completion of cognitive assessments or who refuse consent may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a nationwide observational study using a multistage cluster sampling design to measure direct and indirect costs and quality-of-life impacts of Alzheimer's disease and aMCI in Mainland China. Hospitals across 31 provinces are sampled, with patients selected from those hospitals and assessed using validated scales and interviews. The analysis will use regression and machine learning to identify factors linked to economic burden and QoL, aiming to inform care strategies and policy planning.

Why it matters

Potential benefit: Findings could guide resource allocation and caregiver support programs to reduce economic and QoL burdens.

How similar studies have gone: Other studies have used similar methods to quantify economic burden in AD, but this nationwide approach in China is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Diagnosed according to the National Institute on Aging-Alzheimer's 1.Association (NIA-AA) criteria for aMCI and AD.

2.Clinical Dementia Rating (CDR) score greater than or equal to 0.5 3.Have good visual, auditory, and language functions, or can complete neuropsychological assessments after correction.

4.Participants or their legal representatives sign informed consent. Exclusion criteria

1. History of stroke with neurological focal signs and imaging findings consistent with cerebral small vessel disease (Modified Fazekas score ≥2).
2. Presence of mental or neurological developmental delay.
3. Presence of other known conditions that may cause cognitive impairment.
4. Diagnosis of a disease that prevents completion of cognitive assessments.
5. Refusal to sign informed consent at baseline.

Where it's running

  • Xuanwu Hospital, Capital Medical University
    Beijing, China
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.