Head-to-Head Comparison of BoNT-A Treatments for Glabellar Lines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, multicenter trial compares all five FDA-approved BoNT-A products for treating moderate to severe glabellar lines in adult women. Participants will receive one BoNT-A formulation, with follow-up through 16 weeks and weekly selfie photos to document changes. Blinding is maintained to avoid bias, and safety is monitored throughout. Data will be analyzed for duration of effect and adverse events, using standard clinical scales and Kaplan-Meier methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 years or over, with moderate to severe glabellar lines
* Willing to provide written informed consent
* American Society of Anesthesiologists (ASA) Physical Status Classification 1 or 2
* Negative pregnancy test

Exclusion Criteria:

* ASA Classification 3 or over
* History of hypersensitivity or adverse reactions to botulinum toxin or any of its components
* Infection at the injection site
* Previous treatment with botulinum toxin (lifetime)
* Pregnant or breastfeeding women
* Neuromuscular disorders or conditions that could interfere with the study assessments

Where it's running

• Faceland
  Amsterdam, Netherlands Recruiting
• Faceland
  Eindhoven, Netherlands Recruiting
• Faceland
  Utrecht, Netherlands Recruiting

Study contacts

• Principal investigator: Jan de Lange, MD DMD PhD — Amsterdam UMC, location VUmc
• Study coordinator: Serge A. Steenen, MD DMD
• Email: s.a.steenen@amsterdamumc.nl
• Phone: +316 26 457 415

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.