Hand ultrasound and clinical follow-up after carpal tunnel release

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort of patients with primary carpal tunnel syndrome undergoing standardized open carpal tunnel release at a tertiary university hospital. High-resolution ultrasound will measure median nerve cross-sectional area at the carpal tunnel inlet and outlet before surgery and at 3 and 6 months after surgery. Patients will also complete the Boston Carpal Tunnel Questionnaire and QuickDASH and undergo grip/pinch strength and tactile sensibility testing at the same time points. The study aims to link morphological changes on ultrasound with functional and symptomatic recovery and to identify prognostic factors for improvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of primary carpal tunnel syndrome (CTS), confirmed by characteristic symptoms, physical examination findings, and a cross-sectional area superior to 10 mm² in the ultrasonography baseline.
* Indication for open carpal tunnel release as part of routine clinical care.

Exclusion Criteria:

* Secondary CTS due to inflammatory arthritis, prior wrist trauma, or space-occupying lesions.
* History of previous carpal tunnel release in the affected hand.
* Concomitant peripheral neuropathies (e.g., diabetic polyneuropathy) or cervical radiculopathy
* Inability to undergo ultrasound assessment

Where it's running

• Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da FMUSP
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Marcelo Rosa Rezende, MD, PhD, — Hospital Das Clínicas Da Faculdade de Medicina Da Universidade de São Paulo (Hcfm/usp)
• Study coordinator: Joao Carlos Rodrigues, MD, PhD
• Email: joao.r@hc.fm.usp.br
• Phone: +55112661-6909

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.