Gut and saliva microbiota changes after taking Bacillus coagulans probiotics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adults aged 18–65 will take a freeze-dried Bacillus coagulans probiotic daily for 14 days and collect saliva and fecal samples before and after the intervention. Samples will be frozen immediately and analyzed at Lund University using Illumina MiSeq sequencing and the QIIME2 pipeline to measure species composition, diversity, and relative abundance. People with gastrointestinal disease, autoimmune conditions, recent antibiotic use, or who consume other probiotic products or fermented foods are excluded. The study asks whether the probiotic produces changes in microbiota composition that would be considered beneficial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• You must be 18-65 years of age.

Exclusion Criteria:

* Participants must not be diagnosed with gastrointestinal diseases, autoimmune diseases or have diseases or medications that cause immune deficiency such as MS, type 1 diabetes, cancer or HIV.
* Participants must not have taken antibiotics in the month before or during the study.
* Participants must not consume other probiotic products or fermented foods during the study.

Where it's running

• Department of Process and Life Science Engineering, Lund University
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Åsa Håkansson, Associate Professor — Lund University, LTH
• Study coordinator: Åsa Håkansson, Associate Professor
• Email: asa.hakansson@ple.lth.se
• Phone: +46 46 2228326

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.