Guiding PEEP adjustments in patients with pulmonary fibrosis on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with pulmonary fibrosis and usual interstitial pneumonia who require mechanical ventilation due to acute respiratory failure. It aims to document the effects of adjusting positive end-expiratory pressure (PEEP) based on trans-pulmonary pressure measurements. By optimizing lung mechanics and oxygenation, the study seeks to improve clinical outcomes for these patients, who often face poor prognoses. The approach is novel as it specifically targets the unique challenges posed by fibrotic lungs during mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* pulmonary fibrosis with UIP pattern
* subjected to endotracheal intubation and controlled mechanical ventilation for acute respiratory failure
* candidate to a trial of PEEP titration according to positive end expiratory pressure.

Exclusion Criteria:

* chest wall deformities
* chronic obstructive pulmonary disease

Where it's running

• Azienda Ospedaliero Universitaria Policlinico di Modena
  Modena, Italy Recruiting

Study contacts

• Study coordinator: Roberto Tonelli
• Email: roberto.tonelli@me.com
• Phone: 0039 0594225934

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.