Guiding PEEP adjustments in patients with pulmonary fibrosis on mechanical ventilation
End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation
This study is testing if adjusting a specific breathing support setting can help patients with pulmonary fibrosis on mechanical ventilation breathe better and improve their health outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University of Modena and Reggio Emilia Academic / other |
| Locations | 1 site (Modena) |
| Trial ID | NCT05098717 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with pulmonary fibrosis and usual interstitial pneumonia who require mechanical ventilation due to acute respiratory failure. It aims to document the effects of adjusting positive end-expiratory pressure (PEEP) based on trans-pulmonary pressure measurements. By optimizing lung mechanics and oxygenation, the study seeks to improve clinical outcomes for these patients, who often face poor prognoses. The approach is novel as it specifically targets the unique challenges posed by fibrotic lungs during mechanical ventilation.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with pulmonary fibrosis exhibiting a UIP pattern who are undergoing controlled mechanical ventilation for acute respiratory failure.
Not a fit: Patients with chest wall deformities or chronic obstructive pulmonary disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance oxygenation and reduce complications in patients with pulmonary fibrosis.
How similar studies have performed: While similar approaches have been explored in patients with acute respiratory distress syndrome, the specific application to pulmonary fibrosis has not been extensively documented, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * pulmonary fibrosis with UIP pattern * subjected to endotracheal intubation and controlled mechanical ventilation for acute respiratory failure * candidate to a trial of PEEP titration according to positive end expiratory pressure. Exclusion Criteria: * chest wall deformities * chronic obstructive pulmonary disease
Where this trial is running
Modena
- Azienda Ospedaliero Universitaria Policlinico di Modena — Modena, Italy (Recruiting)
Study contacts
- Study coordinator: Roberto Tonelli
- Email: roberto.tonelli@me.com
- Phone: 0039 0594225934
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.