Guided bone regeneration after tooth extraction using a resorbable membrane (Plenum Guide)
Official title: Guided Bone Regeneration Using Polydioxanone (PDO) Membrane in Sockets After Tooth Extraction: a Clinical Trial
Run by M3 Health · NCT06015906 · Data updated 2026-11-12
This study tests whether a resorbable membrane (Plenum Guide) used with or without surrounding tissue can better preserve the socket bone after tooth extraction, compared with not using the membrane.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | M3 Health Industry-sponsored |
| Locations | 1 site (Araraquara, São Paulo) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | October 7, 2026 |
| Study ends | December 2026 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT06015906 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 who have four bone walls after extraction and sign the consent form.
✕Probably not a fit
Patients with uncontrolled systemic conditions, infections, smoking, radiation to the head/neck region, or allergies to study materials may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants who have a tooth extracted will receive guided bone regeneration using regenerative membranes and a synthetic bone graft, followed by dental implant placement. The study compares five socket conditions to see which approach best maintains bone volume during healing. Outcomes focus on bone preservation in the extraction socket before implants are placed. The trial is conducted at a university hospital in Araraquara, Brazil, led by M3 Health with collaboration from São Paulo State University.
Why it matters
Potential benefit: If successful, the membrane-based approach could improve socket bone preservation, potentially leading to more stable and faster dental implants.
How similar studies have gone: Past studies using resorbable membranes for socket preservation have shown mixed results; this design tests specific membrane exposure scenarios.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Possess the four bone walls after the extraction procedure; * Over 18 years old; * And who have signed the TCLE. Exclusion Criteria: * Uncontrolled systemic impairments; * Teeth in areas of tumor lesions; * Acute infectious processes; * Deciduous dental elements; * Untreated periodontal problems; * Smokers; * Radiated in the head or neck region; * Allergy to any component used in the research; * Psychological disorders; * Pregnant and lactating women.
Where it's running
-
Faculdade de Odontologia de Araraquara
Araraquara, São Paulo, Brazil Recruiting
Study contacts
- Study coordinator: Eduardo Hochuli Vieira, PhD
- Email: eduardo.hochuli@unesp.br
- Phone: +55(16)3301-6459
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.