Growth and development in infants after liver transplant
Official title: Longitudinal Study on Physical Growth in Children After Liver Transplantation
Run by RenJi Hospital · NCT07574398 · Data updated 2026-11-12
We will track how babies up to 1 year old grow and develop over time after a liver transplant to find patterns that can improve follow-up care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 1 Year |
| Sex | All |
| Enrollment | 275 (estimated) |
| Sponsor | RenJi Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | November 20, 2024 |
| Main results expected | December 31, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT07574398 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Infants (≤1 year old) with end-stage liver disease approved for a first liver transplant whose parents or legal guardians provide written informed consent.
✕Probably not a fit
Children older than one year, those undergoing combined liver-kidney transplantation, or those receiving a second liver transplant are excluded and unlikely to benefit from this study's data.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, large-sample, long-term longitudinal observational project at Ren Ji Hospital follows infants who undergo first-time liver transplantation. Eligible participants are children aged ≤1 year with end-stage liver disease whose parents/legal guardians provide written informed consent; combined liver-kidney transplants and repeat liver transplants are excluded. Investigators will collect serial growth measurements (weight, length/height) and developmental milestone data at scheduled post-transplant visits to describe trends and characteristics over time. Findings are intended to inform intervention strategies and optimize follow-up protocols for pediatric liver transplant recipients.
Why it matters
Potential benefit: If successful, the results could help clinicians detect and address growth or developmental delays earlier and tailor follow-up care for infant liver transplant recipients.
How similar studies have gone: Prior pediatric transplant cohorts have reported partial catch-up growth after liver transplantation, but comprehensive long-term, large-sample longitudinal data focused specifically on infants at a single center are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children with end-stage liver disease of various etiologies requiring liver transplantation. * Approved by the ethics committee, and written informed consent has been obtained from the parents/legal guardians. * Age ≤ 1 year (infancy). Exclusion Criteria: * Age older than 1 year old. * Accept liver kidney combined transplantation surgery or second liver transplantation surgery.
Where it's running
-
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.