Group-based interventions for managing Long COVID symptoms

Interventions to Teach Self-management Skills for Persisting Symptoms of COVID-19: Minimizing Impact of Symptoms on Everyday Functioning and on Healthcare Usage/utilization

Not applicable Interventional Toronto Rehabilitation Institute · NCT05268523

This study is testing whether online group sessions that teach about Long COVID and mindfulness can help people manage their ongoing symptoms after recovering from COVID-19.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment270 (estimated)
Ages18 Years and up
SexAll
SponsorToronto Rehabilitation Institute Academic / other
Locations1 site (Toronto, Ontario)
Trial IDNCT05268523 on ClinicalTrials.gov

What this trial studies

This study investigates the feasibility and efficacy of two group-based interventions—education and mindfulness skills—to help individuals self-manage symptoms of Long COVID. Participants will be divided into three groups: one receiving education about Long COVID and self-care strategies, another practicing mindfulness techniques, and a control group receiving no treatment. The interventions will be delivered online by licensed therapists over eight weeks, with sessions lasting 1.5 hours each week. The study aims to gather both qualitative and quantitative data to assess the effectiveness of these approaches in alleviating persistent symptoms following COVID-19 infection.

Who should consider this trial

Good fit: Ideal candidates include adults over 18 years old who have been clinically diagnosed with Long COVID and report multiple persisting symptoms.

Not a fit: Patients with severe Long COVID symptoms that interfere with their ability to participate in the intervention may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide effective self-management strategies for patients suffering from Long COVID symptoms.

How similar studies have performed: Other studies have explored self-management interventions for chronic conditions, showing promising results, but this specific approach for Long COVID is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinically diagnosed Long-COVID plus PCR positivity with and without hospitalization
* 3-12 months post-diagnosis of COVID-19
* \>2 self-reported persisting symptoms in \>1 mood, cognitive and/or somatic symptom domain
* Age \>18
* English speaking
* Private access to computer/internet

Exclusion Criteria:

* Acute ventilator support
* Diagnosed dementia
* Past/present history of psychotic illness or mania and, because of potential overlap in symptoms, diagnosis of chronic fatigue syndrome, fibromyalgia, chronic lyme disease or traumatic brain injury
* Long-COVID symptom severity (i.e., physical, cognitive, emotional symptoms) at a level that would significantly interfere with attendance/adherence to the intervention protocol

Where this trial is running

Toronto, Ontario

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions COVID-19Long-term effectsSelf-managementGroup therapyTelerehabilitation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.