Goal-directed IV fluid management using cardiac index versus central venous pressure after major abdominal surgery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult patients having elective major abdominal surgery with planned ICU admission will receive goal-directed fluid therapy during the first six postoperative hours guided either by cardiac index or by central venous pressure. Total fluid volumes administered will be compared between the two approaches, along with outcomes such as mortality, ICU/hospital length of stay, relaparotomy, and reintubation. Patients are selected based on age, BMI, and ASA status, with several cardiovascular, renal, rhythm, and pregnancy exclusions. The trial is conducted at a single tertiary center and focuses on early postoperative hemodynamic management in the ICU.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 to 65 years.
* Patients with a Body Mass Index (BMI) between 18 and 30 kg/m².
* Patients undergoing elective major abdominal surgery with a planned postoperative admission to the ICU.
* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I to III.

Exclusion Criteria:

* Patients with pre-operative cardiovascular disorders (Coronary Artery Disease, or heart failure NYHA Class III and IV).
* Patients with severe renal impairment (Chronic Kidney Disease Stage V) with or without hemodialysis and fluid restrictions.
* Non-sinus cardiac rhythm.
* Pregnancy.
* Patients with right heart failure (patients with signs of congestion and symptoms of right heart failure accompanied by evidence of reduced right ventricular function, indicated by TAPSE \< 17 mm).
* Patients with pulmonary hypertension (patients with echocardiographic suspicion of tricuspid regurgitation, tricuspid regurgitation velocity \> 3.4 m/s, or mean pulmonary artery pressure \> 20 mmHg from right heart catheterization).
* Patients with Acute Respiratory Distress Syndrome (ARDS) or patients requiring specialized ventilation modes.
* Patients who refuse to participate in the study.

Where it's running

• Cipto Mangunkusumo Hospital
  Jakarta Pusat, DKI Jakarta, Indonesia Recruiting

Study contacts

• Study coordinator: Sidharta Kusuma Manggala, dr.
• Email: maninjau3@gmail.com
• Phone: +6281281772295

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.