GnRH for luteal support in IVF with a GnRH antagonist protocol
Official title: Gonadotropin-Releasing Hormone Agonist as a Single Luteal Support - What is Its Mechanism of Action?
Run by Shaare Zedek Medical Center · NCT07620067 · Data updated 2026-11-12
This observational study tests whether using a GnRH agonist or vaginal progesterone as luteal support helps pregnant outcomes for women undergoing IVF with a GnRH antagonist protocol and fresh embryo transfer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Shaare Zedek Medical Center Academic / other |
| Locations | 1 site (Jerusalem) |
| Status | Recruiting |
| Started | May 18, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 2, 2026 |
| Trial ID | NCT07620067 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-45 undergoing IVF with a GnRH antagonist protocol and planning a fresh embryo transfer, within their first to third treatment cycle.
✕Probably not a fit
Patients who do not respond to luteal support or have factors limiting implantation may not see a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study at Shaare Zedek Medical Center in Jerusalem, enrolling women undergoing IVF with a GnRH antagonist protocol and a fresh embryo transfer. Participants will receive luteal phase support with either intranasal GnRH agonist or vaginal progesterone, while biomarkers in blood and follicular fluid are measured at predefined time points to explore hormonal, inflammatory, and angiogenic changes. The study aims to illuminate the mechanism of action of GnRH agonists used for luteal support and identify predictors of treatment success or failure. It will collect data on LH, FSH, estradiol, progesterone, IL-6, IL-8, VEGF, PEDF, and relaxin to correlate with pregnancy outcomes. Findings may inform future optimization of luteal support in IVF with antagonist protocols.
Why it matters
Potential benefit: If successful, the study could clarify how GnRH agonists work as luteal support and help improve pregnancy outcomes for IVF patients.
How similar studies have gone: Previous work, including a prospective randomized study from the same group, has suggested improved pregnancy rates with GnRH agonist luteal support, but the exact mechanism remains uncertain.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women included in the study will be 18-45 years old * undergoing IVF treatments due to ovulation disorder, mechanical factor, primary ovarian insufficiency, or male infertility. * All women will be at their first to the third cycle of treatment * women will undergo a fresh ET. Exclusion Criteria: * repeated implantation failure (more than 3 cycles of good quality ET without implantation) * moderate-severe endometriosis * hydrosalpinx * fibroid uterus * BMI more than 35 or less than 19 * women with hypogonadotropic hypogonadism * PGT of embryos * use of surgical techniques for sperm retrieval * preference of the long GnRH-agonist protocol * women with rhinitis or nasal congestion.
Where it's running
-
Shaare Zedek Medical Center
Jerusalem, Israel Recruiting
Study contacts
- Study coordinator: Heli Alexandroni, MD
- Email: heli.alexandroni@gmail.com
- Phone: +972-6666055
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.