Glycolytic Power and Muscle Growth Response to Resistance Training

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter study looks at whether the glycolytic phenotype, measured by the vLapeak lactate peak during a short all-out sprint, can forecast lower-body muscle hypertrophy after an 8-week resistance program. Participants will undergo the vLapeak test, then complete twice-weekly supervised leg-focused training with progressively challenging loads. Muscle size will be assessed with ultrasound before and after training, while blood metabolomics and optional muscle biopsies explore metabolic changes that relate to hypertrophy. The study uses a single-arm design to link metabolic phenotype with physical adaptation in healthy adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Body Mass Index (BMI) between 20-29 kg/m2
* No structured resistance training performed in the last twelve months.
* Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
* No history of competitive strength or physique sports.

Exclusion Criteria:

* Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
* Positive response to any question on the PAR-Q 2025 questionnaire.
* Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
* Regular engagement in shift work.
* Women who are pregnant or breastfeeding.

Where it's running

• University of Jyväskylä, Faculty of Sport and Health Sciences
  Jyväskylä, Central Finland, Finland Recruiting
• Technical University of Munich, TUM School of Medicine and Health
  München, Bavaria, Germany Recruiting
• DLR Cologne, Department of Metabolism and Human Performance
  Cologne, North Rhine-Westphalia, Germany Recruiting
• iST University of Applied Sciences
  Düsseldorf, North Rhine-Westphalia, Germany Recruiting
• TU Chemnitz, Sports Medicine and Exercise Therapy
  Chemnitz, Saxony, Germany Recruiting
• Institute for Applied Training Science (IAT) Leipzig
  Leipzig, Saxony, Germany Recruiting

Study contacts

• Study coordinator: Henning Wackerhage, Prof. Dr.
• Email: henning.wackerhage@tum.de
• Phone: +49 89 289 24480

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.