Glycogen Storage Disease and Brain Function in People Like You

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study that compares cognitive test results and brain MRI findings between people with glycogen storage disease and age- and sex-matched healthy controls. Participants will complete cognitive assessments, undergo a brain MRI on a 3-tesla scanner, and provide medical history. No treatment is given as part of the study, and researchers will explore relationships between imaging findings, cognitive performance, and metabolic history. The study aims to identify potential brain structure or blood flow differences associated with GSD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

GSD group:

* Meeting the diagnostic criteria for GSD
* Having relatively complete clinical data
* Able to cooperate with cognitive assessments and neuroimaging examinations

Control group:

* Age within 5 years of GSD patients, matched for sex, and with similar educational level
* No diagnosis of GSD
* No chronic metabolic diseases such as hypertension, diabetes mellitus, or hyperlipidemia; no history of heavy smoking or alcohol drinking; and no history of hypoglycemia in childhood

Exclusion Criteria:

* Concurrent diagnosis of other neurological disorders
* Presence of factors that may cause central nervous system (CNS) injury, such as premature birth or head trauma
* Contraindications to magnetic resonance imaging
* Inability of the patient or their family members to understand the conditions and objectives of this study

Where it's running

• Peking Union Medical College Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Chang Liu
• Email: rosajessica@126.com
• Phone: +86 18813105716

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.