Glycine and magnesium plus thiamine for primary ciliary dyskinesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

People with confirmed primary ciliary dyskinesia (PCD) who are at least 5 years old will continue their usual care and be assigned to receive oral glycine, magnesium plus thiamine, the combination, or placebo for six months. The study will track lung function, respiratory symptoms, frequency of respiratory exacerbations, and safety/tolerability during the treatment period. Participants must be clinically stable with no respiratory exacerbation or acute infection in the prior 30 days and will attend the Mexico City site for scheduled visits and testing. The supplements are inexpensive, taken orally, and intended as adjuncts to standard airway clearance measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Any sex.
2. Age of 5 years or more.
3. Diagnosis of primary ciliary dyskinesia (PCD) established according to international recommendations (Shapiro et al. Am J Respir Crit Care Med 2018;197(12):e24-e39, and Shapiro et al. Ped Pulmonol 2016;51:115-132).
4. Without respiratory exacerbations of PCD in the previous 30 days.
5. Without acute respiratory infection in the previous 30 days.
6. Informed consent letter signed by the patient (if the patient's age is 18 years or more).
7. Informed consent letter signed by the legal guardian, and assent letter signed by the patient (if the patient's age is \<18 years).

Exclusion Criteria:

1\. Participation in other research protocol involving therapeutic measures.

Elimination Criteria:

1\. None.

Where it's running

• Instituto Nacional de Enfermedades Respiratorias
  Mexico City, Mexico Recruiting

Study contacts

• Principal investigator: Mario H. Vargas, MSc — 5556665868
• Study coordinator: Mario H. Vargas, MSc
• Email: mhvargasb@yahoo.com.mx
• Phone: 5556665868

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Thermal spa treatment to improve symptoms of primary ciliary dyskinesia

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• Observational study on Primary Ciliary Dyskinesia

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  Recruiting at 18 sites Institut National de la Santé Et de la Recherche Médicale, France · Besançon and 31 other locations · NCT05951478

• Using nasal nitric oxide testing to improve diagnosis of primary ciliary dyskinesia

  This study is testing if a simple nasal test can help doctors diagnose primary ciliary dyskinesia in people aged 2 and older who show symptoms of the condition.

  Recruiting Connecticut Children's Medical Center · Hartford, Connecticut · NCT05889013

• Nasal nitric oxide testing for better care in primary ciliary dyskinesia

  This study is trying to see if measuring nitric oxide in the nose can help doctors diagnose primary ciliary dyskinesia more accurately for patients at Arkansas Children's Hospital.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.