Glutamine-based PET/CT to detect cancer using 18F-FGln in patients with suspected or known tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the diagnostic performance of 18F-FGln PET/CT for detecting and characterizing malignant tumors across a range of cancer types, using histopathology as the reference standard. It builds on prior safety and feasibility data for 18F-FGln and explores its potential to improve diagnostic accuracy compared with or alongside standard 18F-FDG PET/CT. Eligible participants include adults with suspected or known cancers where 18F-FDG may yield false results, and those undergoing staging or treatment assessment. The study aims to determine how well 18F-FGln PET/CT identifies tumors and informs management decisions. No interventional treatment is described in the protocol, and imaging is performed as part of diagnostic evaluation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with clinical suspicion or exclusion of primary or recurrent malignant tumors (such as glioma of the brain, liver cancer, gastric cancer, duodenal cancer, colorectal cancer, ovarian cancer, etc., where 18F-FDG is prone to false negatives and false positives)
2. Patients undergoing tumor staging or evaluating treatment effect using 18F-FDG PET/CT or 18F-FGln PET/CT to determine the most appropriate treatment strategy
3. Patients without other tumor history
4. Patients with good compliance, providing informed consent, and able to follow the research protocol

Exclusion Criteria:

1. pregnant or lactating patients or patients under 18 years old
2. the subjects and their parents or legal representatives are unable or unwilling to provide written informed consent;
3. patients with poor compliance, unable to tolerate or cooperate with PET/CT examinations.
4. those who have undergone gastrointestinal barium meal examination within one week;
5. other situations where the investigators consider it inappropriate for the subjects to participate in this clinical trial

Where it's running

• Affiliated Cancer Hospital & Institute of Guangzhou Medical University
  Guangzhou, China Recruiting

Study contacts

• Study coordinator: Rusen Zhang
• Email: zhangrusen2015@163.com
• Phone: 0086-13642328295

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.