Global trial to find effective treatments for stroke
Official title: A Multi-faCtorial, mulTi-arm, Multi-staGe, Randomised, gLOBal Adaptive pLatform Trial for Stroke (ACT-GLOBAL)
Run by The George Institute · NCT06352632 · Data updated 2026-11-12
This study is testing different treatments for stroke patients to see which ones work best to improve their recovery.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20000 (estimated) |
| Sponsor | The George Institute Academic / other |
| Locations | 2 sites (Sydney, New South Wales and 1 other locations) |
| Status | Recruiting |
| Started | September 26, 2024 |
| Main results expected | September 2034 |
| Study ends | September 2034 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT06352632 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years and older who have been clinically diagnosed with a stroke.
✕Probably not a fit
Patients who do not have a clinical diagnosis of stroke or are under 18 years old may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
ACT-GLOBAL is a multi-factorial, multi-arm, multi-stage adaptive platform trial designed to identify the most effective treatments for stroke patients. The trial evaluates various interventions, including different doses of intravenous tenecteplase and blood pressure control strategies, to determine their impact on patient outcomes. By conducting frequent adaptive analyses, the study aims to assess the efficacy of these treatments in real-time, allowing for adjustments based on accumulating data. This innovative approach seeks to address the urgent need for improved stroke interventions that can be widely applied.
Why it matters
Potential benefit: If successful, this trial could lead to more effective treatment options for stroke patients, potentially reducing mortality and disability rates.
How similar studies have gone: Other adaptive platform trials have shown promise in identifying effective treatments for various conditions, suggesting that this approach could yield valuable insights for stroke management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Platform Inclusion Criteria: 1. Age ≥18 years 2. Clinical diagnosis of stroke Platform Exclusion Criteria: There are no platform level exclusion criteria Each state and domain will specify additional inclusion and exclusion criteria in the respective Domain-Specific Registration. Patients who fulfill the overall platform criteria will be assessed for enrollment into each active domain.
Where it's running
-
The George Institute for Global Health
Sydney, New South Wales, Australia Recruiting -
University of Calgary
Calgary, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Craig Anderson, MD, PhD — The George Institute
- Study coordinator: Xiaoying Chen, PhD
- Email: xchen@georgeinstitute.org.au
- Phone: +61280524549
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
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AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
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Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
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Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
-
Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.