Gingivitis in kids vs young adults: comparing fluid biomarkers in the mouth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this prospective observational study, researchers will recruit about 80 healthy participants with gingivitis, split into children (8-12) and young adults (15-24). They will measure clinical periodontal parameters and collect gingival crevicular fluid from tooth #31 to analyze IL-1β, TNF-α, IL-10, and MMP-8 using ELISA. The goal is to see age-related differences in inflammatory and anti-inflammatory biomarker profiles. Exclusions include ages 13-14, systemic diseases, recent periodontal treatment, and other factors that could confound results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Individuals aged 8-12 years (child group) or 15-24 years (young adult group)
2. Clinical diagnosis of gingivitis
3. Presence of fully erupted tooth #31 with closed apex
4. Systemically healthy individuals
5. No history of periodontal treatment in the last 3 months
6. No antibiotic or anti-inflammatory drug use in the last 3 months
7. Good cooperation and willingness to participate
8. Written informed consent from participants or legal guardians (for minors)

Exclusion Criteria:

1. Age 13-14 years (transitional pubertal period)
2. Presence of periodontitis or other periodontal diseases
3. Systemic, genetic, or immunological diseases
4. Acute oral infections or conditions requiring emergency treatment
5. Orthodontic appliances in the sampling region
6. Smokers
7. Pregnant or lactating individuals
8. Individuals with cognitive, psychological, or physical disabilities affecting cooperation
9. Inadequate eruption or incomplete root development of tooth #31
10. Refusal to participate or withdrawal of consent

Where it's running

• Niğde Ömer Halisdemir University Faculty of Dentistry
  Niğde, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Aycan Dal Dönertaş
• Email: aycandal@outlook.com
• Phone: +903382252595

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.