Getting off the ventilator after acute brain injury
Weaning Outcomes in Patients With Acute Brain Injury Based on CDIC
Southeast University, China · NCT07496125
This study tries to see if patterns of taking adults with acute brain injury off ventilators are linked to their outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Southeast University, China (other) |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT07496125 on ClinicalTrials.gov |
What this trial studies
This is a retrospective observational analysis of adults with acute brain injury who received invasive mechanical ventilation for at least 24 hours at Zhongda Hospital. Investigators used the modified WIND classification to characterize the weaning process, duration, and success rates. Patients who were already tracheostomized, had cervical spinal cord injury, were pregnant, or had life support withdrawn within 24 hours were excluded. The analysis aims to describe weaning trajectories and associated complications and outcomes in this single-center cohort.
Who should consider this trial
Good fit: Adults (age ≥18) with acute brain injury who required invasive mechanical ventilation for at least 24 hours and received care at Zhongda Hospital are the intended population.
Not a fit: Patients who were already tracheostomized, had cervical spinal cord injury, were pregnant or breastfeeding, or had life-sustaining treatment withdrawn within 24 hours are excluded and may not benefit from the findings.
Why it matters
Potential benefit: If patterns associated with safer or faster liberation from ventilators are identified, clinicians could adjust timing and methods to reduce ventilator-related complications.
How similar studies have performed: Ventilator weaning has been studied broadly, but studies applying the modified WIND classification specifically to patients with acute brain injury are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with ABI * ≥ 18 years old * underwent IMV for at least 24 hours Exclusion Criteria: * already tracheostomized * concurrent of cervical spinal cord injury * pregnant or lactation * withdraw of life-sustaining treatment within the first 24 hours of ICU admission
Where this trial is running
Nanjing, Jiangsu
- Department of Critical Care Medicine, Zhongda Hospital — Nanjing, Jiangsu, China (RECRUITING)
Study contacts
- Study coordinator: Ling Liu, PHD
- Email: liulingdoctor@126.com
- Phone: 86+83262553
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Brain Injuries, Mechanical Ventilation