Gestational diabetes and health outcomes for mothers and babies
Understanding the Effects of Gestational Diabetes on Mother and Baby
Medical University of Graz · NCT07459907
This project will follow pregnant women with gestational diabetes to see how the condition affects mothers and their babies during pregnancy, delivery, and early postpartum.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Medical University of Graz (other) |
| Locations | 1 site (Graz) |
| Trial ID | NCT07459907 on ClinicalTrials.gov |
What this trial studies
This prospective, single-center observational cohort will recruit pregnant women diagnosed with gestational diabetes after a positive 75 g oral glucose tolerance test, typically between gestational weeks 24 and 28. Participants will attend two study visits during pregnancy, provide clinical samples at delivery, and complete a postpartum visit 8–12 weeks after birth, with clinical data, physical measurements, questionnaires, and biological samples collected from mothers and infants. Approximately 100 women will be enrolled per year at the Department of Obstetrics and Gynecology of the Medical University of Graz, and women with major fetal anomalies or diagnosis after 32 weeks are excluded. The collected data and biosamples are intended for comprehensive phenotyping to help define mechanisms and early-life outcomes associated with gestational diabetes.
Who should consider this trial
Good fit: Pregnant women aged 18 years or older with an ongoing pregnancy before 32 weeks and a positive 75 g oral glucose tolerance test are ideal candidates.
Not a fit: Women diagnosed after the 32nd gestational week, pregnancies with major fetal anomalies, or those unwilling to attend study visits or provide samples are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the project could improve understanding of how gestational diabetes affects short- and long-term health and inform better prevention or follow-up strategies for mothers and children.
How similar studies have performed: Other longitudinal gestational diabetes cohorts have provided useful insights into maternal and offspring cardiometabolic risk, so this approach is established though mechanisms remain incompletely understood.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ongoing pregnancy prior to the 32nd gestational week and a positive GDM screening Exclusion Criteria: * gestational age 32nd gestational week * fetal genetic anomalies /malformation
Where this trial is running
Graz
- Department of Obstetrics and Gynecology, Medical University of Graz — Graz, Austria (RECRUITING)
Study contacts
- Principal investigator: Christina Stern, Dr. med. — Medical University of Graz
- Study coordinator: Evelyn Jantscher-Krenn, PhD
- Email: evelyn.jantscher-krenn@medunigraz.at
- Phone: +43 316 385 80076
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Gestational Diabetes Mellitus, Pregnancy, GDM, Insulin resistance, Glucose metabolism, Cardiometabolic risk, Pregnancy outcomes, Pregnancy phenotyping