Genotyping cell-free DNA in lung cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the genotyping of cell-free DNA obtained from the supernatant of EBUS-TBNA procedures in patients with non-small cell lung cancer (NSCLC). It aims to improve the accuracy of tumor genotyping by utilizing liquid biopsy techniques, which are less invasive than traditional tissue biopsies. The study addresses the challenge of limited tissue availability for multiplex analysis of various targetable mutations and markers, particularly in patients with advanced disease. By analyzing the molecular profile of tumors through minimally invasive methods, the study seeks to enhance treatment decision-making for lung cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years-old
* Patients planned for an EBUS-TBNA for

  1. Suspicion of stage IV lung cancer (PET+ mediastinal node(s)) (Cohort 1)
  2. Stage IV NSCLC with an EGFR, BRAF, HER2, MET mutation or ALK, RET or ROS1 rearranged NSCLC and acquired resistance to targeted therapy (Cohort 2)
* Performance status 0-3
* Informed consent

Exclusion Criteria:

* Refusal to participate
* Patient under legal tutelage

Where it's running

• Nicolas Guibert
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Nicolas Guibert — University Hospital, Toulouse
• Study coordinator: Nicolas Guibert, MD
• Email: guibert.n@chu-toulouse.fr
• Phone: 567778160

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.