Genetic links to myopia in children and adolescents

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will collect DNA via oral swab from participants aged 6–18 and analyze myopia-related gene variants. Researchers will link genetic data to clinical measures such as spherical equivalent refraction and axial length change, and they will record participants' use of common myopia control measures (low-dose atropine, orthokeratology, specialized lenses, and time outdoors). The team will model gene-by-treatment interactions to see whether genetic profiles modify treatment response and disease progression. Finally, investigators will develop a genetic risk score intended to support personalized myopia prevention and treatment strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 6-18 years.
* Any Spherical equivalent refraction (SER)
* Parental consent for genetic testing.

Exclusion Criteria:

* Suspected genetic syndromes (e.g., Stickler, Marfan).
* Other eye diseases (e.g., glaucoma, cataracts, retinal abnormalities, strabismus).
* Prior refractive surgery

Where it's running

• Beijing New Vision Eye Hospital
  Beijing, China Recruiting
• Beijing Visionly Plus Eye Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Lin Yang, M.D.
• Email: roc001cn@gmail.com
• Phone: +86-17898805125

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating a device for screening vision problems in young children

  This study is testing a new device to see if it can effectively find vision problems in children aged 3 to 8, whether they wear glasses or not.

  Recruiting Essilor International · Nancy, France and 1 other locations · NCT06882408

• Optimizing light exposure to prevent and control myopia in children

  This study tests if changing classroom lighting to mimic sunlight or using a smartphone app to guide light exposure can help prevent and control myopia in primary school children.

  Recruiting at 5 sites National University of Singapore · Singapore and 4 other locations · NCT06631339

• Hyperopic reserve screening for kindergartners in Beijing

  A population-wide screening tests whether senior kindergarten children in Beijing have enough hyperopic reserve to help prevent future myopia.

  Recruiting Beijing Tongren Hospital · Beijing · NCT07851532

• Do dual-focus multifocal contact lenses improve hand-eye coordination and sports vision compared with your usual lenses

  This study tests whether wearing dual-focus multifocal contact lenses improves hand-eye coordination and sports vision in adults who play baseball or softball and normally wear contact lenses.

  Recruiting Ohio State University · Columbus, Ohio · NCT07840209

• Two monthly silicone hydrogel multifocal toric contact lenses in wearers with astigmatism and myopia

  This study tests whether two popular soft multifocal toric contact lenses perform differently in adults who need vision correction for astigmatism and myopia.

  Recruiting CooperVision International Limited (CVIL) · New York, New York and 2 other locations · NCT07829419

• Seeing clearly in low light after Ray-Tracing guided LASIK

  A trial tests how well WaveLight Plus LASIK works for people with myopia and astigmatism and whether patients are satisfied after the procedure.

  Recruiting Phase 4 Vance Thompson Vision · Sioux Falls, South Dakota · NCT07790185

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.