Genetic clues for lichen sclerosus in families

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify genetic variants associated with lichen sclerosus by sequencing exomes or genomes in families where some members are affected and others are not. The approach is exploratory and focuses on segregation of variants within pedigrees to uncover potential Mendelian genes. There are no interventions or clinical endpoints; success is defined by discovery of novel LS-related genes through family-based sequencing. Enrollment prioritizes families with multiple affected individuals to increase the chance of finding meaningful genetic associations. The study is conducted at Medbase in Frauenfeld with collaborating centers involved in the analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individual with clinical or /and histological Lichen sclerosus
* Family member of an individual with lichen sclerosus

Exclusion Criteria:

* No Family member with lichen sclerosus

Where it's running

• Medbase
  Frauenfeld, Thurgau, Switzerland Recruiting

Study contacts

• Principal investigator: Gudula Kirtschig, Dr. — Medbase
• Study coordinator: Gudula Kirtschig, Medical doctor
• Email: g.kirtschig@gmail.com
• Phone: 0041527230202

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.